ArticleCureus2024
Amniotic Fluid Bacterial Colonization, Antibiotic Susceptibility, and Associated Factors Among Women With Premature Rupture of Membranes at Mbarara Regional Referral Hospital, Southwestern Uganda.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmniotic fluid bacterial colonization in premature rupture of membranes (PROM) is known to initiate labor and lead to postpartum endometritis and early-onset neonatal sepsis. We determined the prevalence and factors associated with amniotic fluid bacterial colonization, described bacterial isolates and examined antibiotic susceptibility patterns among women seeking care at Mbarara Regional Referral Hospital (MRRH) in southwestern Uganda.
methodsWe conducted a cross-sectional study from December 21, 2020 to June 12, 2021. We consecutively enrolled women with PROM at ≥24 weeks of gestation and aseptically picked two endo-cervical swabs. Aerobic cultures were performed on blood, chocolate, MacConkey agars, and polymerase chain reaction on culture-negative samples. Antibiotic susceptibility was performed via the Kirby-Bauer disk diffusion and dilution method. Interviewer-administered questionnaires were used to obtain participants' sociodemographic, medical, and obstetric characteristics. We performed multivariable logistic regression to determine factors associated with bacterial colonization.
resultsWe enrolled 144 participants with a mean age of 26.5±6.2 years. The prevalence of cervical amniotic bacterial colonization was 35.4% (n=51; 95% confidence interval (CI): 28.0-43.7). Six bacteria were isolated:
conclusionApproximately one-third of the women had amniotic fluid bacterial colonization, and this was associated with being prime gravida, being obese, and being referred. The most common bacteria isolated was
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