ArticleCureus2024
A Comparative Study on the Efficacy of Intravenous Palonosetron Versus a Combination of Ondansetron and Dexamethasone as Prophylaxis for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Surgeries.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Prophylactic Efficacy of Cipepofol Against Postoperative Nausea and Vomiting in Moderate to High-Risk Patients of Apfel Score: A Multicenter, Randomized, and Parallel-Group Comparative Trial.Drug design, development and therapy · 2026Trial
- OPRM1 A118G Polymorphism and Ondansetron Efficacy for Postoperative Nausea and Vomiting in Laparoscopic Gynaecological Surgery: A Retrospective Cohort Study.Therapeutics and clinical risk management · 2025Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most troublesome complaint after general anaesthesia and surgery, especially laparoscopic surgeries, is postoperative nausea and vomiting (PONV). We routinely use pharmacologic prophylaxis to prevent PONV. In patients undergoing laparoscopic procedures, we assessed the effectiveness of palonosetron compared to ondansetron combined with dexamethasone in preventing the incidence of PONV. METHODS AND MATERIALS: This was a prospective, randomised, double-blind study that included 60 patients aged 18 to 60 years of either sex belonging to ASA physical status I or II undergoing elective laparoscopic surgeries. Before induction of anaesthesia, patients were randomised into two equal groups to receive either 0.075mg of palonosetron (group 1) or 4mg of ondansetron with 4mg of dexamethasone (group 2). Any incidence of nausea or vomiting along with the severity was assessed using the visual analogue scale, and the need for the rescue antiemetic was noted. Statistical analysis was done using an independent sample T-test, chi-square test, and Fisher's exact test. P-value <0.05 was considered statistically significant.
resultsThe overall incidence of PONV was 18% (11 patients), all of which were of mild to moderate severity. The palonosetron group had a lesser incidence of PONV, in three patients (10%) when compared to eight patients (26.6%) in the ondansetron and dexamethasone combination group over a period of 48 hours, but the difference was not statistically significant (P=0.854). The need for the rescue antiemetic was also comparable between both the groups (P=0.129), two patients required the rescue antiemetic (6.66%) in the palonosetron group, while in the ondansetron and dexamethasone group, six patients required the rescue antiemetic (20%).
conclusionBoth palonosetron and ondansetron with dexamethasone prove to be comparably effective in preventing PONV in laparoscopic surgeries and achieving a complete response for a longer period, thus requiring fewer rescue medications with no adverse reaction.
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