ArticleCureus2024
Investigating the Unexpected Effect of Bulkheads in a Dementia Model of Mice Through Molecular Analysis of the Hippocampus.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to evaluate the impact of long-term exposure to physical barriers used as preventive measures during the coronavirus disease 2019 (COVID-19) pandemic on cognitive function and behavior in an apolipoprotein E
methodsApoE
resultsThe partitioned group exhibited reduced exploratory behavior, lower recognition index, and impaired spatial learning compared with the co-housed group. However, the differences were not significant. Based on morphological analysis, the partitioned and isolated groups presented a significant reduction in neuronal density in the hippocampal CA1 region. RNA-sequencing analysis showed significant changes in the expression of genes related to neurotransmitter transport, neurite outgrowth, and neuropeptide signaling pathways.
conclusionsProlonged physical isolation, even with visual contact, can adversely affect cognitive function and hippocampal structure in dementia models. Changes in gene expression indicate that neurotransmitter imbalances and neuroinflammatory responses may contribute to these effects. These findings emphasize the need to develop new infection-prevention measures for patients with dementia during the COVID-19 pandemic.
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