ArticleCureus2024
Comparison of the Efficacy of Transdermal Buprenorphine Versus Ketoprofen Patches for Post-operative Analgesia in Total Knee Arthroplasty: A Randomised Controlled Trial.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comparative Evaluation of Efficacy of Transdermal Buprenorphine Patch versus Intraoperative Cocktail Injection for Post-operative Pain Relief in Total Hip Arthroplasty.Journal of orthopaedic case reports · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction The utilisation of transdermal patches containing buprenorphine (BTP) and ketoprofen (KTP) has been widely documented for post-operative pain management. However, to date, no single study has comprehensively evaluated the efficacy of KTP and BTP specifically in managing post-operative pain following arthroplasty procedures. Methods A total of 100 consecutive patients undergoing primary total knee replacement between August 2022 and January 2023 were randomly assigned into two groups (Group KTP and BTP) using computer-generated numbers. Patients in Group BTP received a buprenorphine patch (10 µg/h) 24 hours before surgery, replaced on the seventh day and sustained for 14 days. Group KTP received a ketoprofen patch (20 mg) on the day of surgery, replaced daily for 14 days. Pain intensity was assessed using the Visual Analog Scale (VAS) score pre-operatively and post-operatively. Clinical outcomes included VAS scores at baseline, on post-operative days (POD) 2, 5, and 14, both at rest and during activity, need for rescue analgesia, adverse events, duration of hospital stay, post-operative range of motion (ROM), and patient satisfaction. Results Results revealed significantly lower VAS scores at rest in the BTP group for the initial five days, with similar trends observed for VAS scores during activity. No significant differences were found in VAS scores at day 14. There was an increased need for rescue analgesia in the KTP group compared to the BTP group. Post-operative ROM was consistently higher in the BTP group, although not statistically significant. Patient satisfaction scores favoured the BTP group throughout admission, with no remarkable adverse effects in either group. Conclusion In conclusion, BTP patches demonstrated enhanced efficacy in managing post-operative pain compared to KTP, without exacerbating side effects in the early stages following total knee arthroplasty. BTP can be definitively considered as an adjuvant in post-operative total knee arthroplasty analgesia.
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