Evidence map›Paper›PMID 39583313›Full record

ArticlePhenomics (Cham, Switzerland)2024

Cell-Free DNA in Plasma Reveals Genomic Similarity Between Biliary Tract Inflammatory Lesion and Biliary Tract Cancer.

Ruimei Liu, Yueqiang Song, Rulin Hua, Shariq Ahmed, Yunxiao Xie, Cong Lai, Jialu Xu, Fuyuan Li, Ying Li, Zhiguang Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phenomics (Cham, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ruimei Liu *State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, 200438 China.
Yueqiang Song *State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, 200438 China.
Rulin Hua *Institute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044 Liaoning China.
Shariq AhmedInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044 Liaoning China.
Yunxiao XieState Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, 200438 China.
Cong LaiState Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, 200438 China.
Jialu XuInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044 Liaoning China.
Fuyuan LiState Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, 200438 China.
Ying LiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044 Liaoning China.
Zhiguang LiInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044 Liaoning China.
Yinping WangDepartment of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001 China.
Dekang LvInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044 Liaoning China.
Qiwei LiDepartment of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Similar clinical manifestations and imaging features between biliary tract inflammatory lesion (BTI) and biliary tract cancer (BTC) pose significant challenges for the management of BTC. To date, the molecular characteristics of the relationship between biliary tract inflammatory lesion and biliary tract cancer remain poorly elucidated. Here, we performed target deep sequencing on 45 BTC patients and 31 BTI patients based on cell-free DNA (cfDNA) in plasma. We characterized the mutational features of 93 cancer-related genes for BTI and BTC. A total of 41% of genes showed concordance between BTI and BTC patients. Mutation burden in cfDNA exhibits a correlation with the levels of cancer antigen 19-9 (CA19-9) ( Supplementary Information: The online version contains supplementary material available at 10.1007/s43657-024-00160-2.

Indexed as

Biliary tract cancerBiliary tract inflammationCell-free DNASomatic mutationTargeted sequencing

Identifiers

PMID39583313
PMCPMC11584818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.