ArticleJournal of conservative dentistry and endodontics2024
Role of Pyrrolidine dithiocarbamate in inducing odontoblastic differentiation of dental pulp stem cells.
Article in Journal of conservative dentistry and endodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Exosome-loaded human amniotic membrane hydrogel modulates regenerative responses of human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2026Article
- Wharton's jelly mesenchymal stem cell-derived exosomes promote odontogenic differentiation of dental pulp stem cells: A cell-free strategy for regenerative endodontics.Journal of conservative dentistry and endodontics · 2026Article
- Effect of biodentine modified with bioactive glass nanoparticles on biocompatibility, osteogenic differentiation, and gene expression of human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pyrrolidine dithiocarbamate (PDTC) is an efficient, reproducible, and biological antioxidant of clinical utility, which may also be preferred for obtaining human dental pulp stem cells (hDPSCs) for the purpose of tissue engineering and regenerative medicine. Aim and Objectives: The study was conducted to evaluate the effects of PDTC on the propagation and differentiation of hDPSCs. Materials and Methods: hDPSCs were isolated by explant culture method and characterized for stem cell properties using flow cytometry method. The effects of PDTC-induced odontoblastic differentiation of hDPSC at different concentrations (0.5, 1.0, and 5.0 mM) were determined by staining for mineralization. Results: Mineralization was more prominent and significantly higher in the induced hDPSCs treated with 1.0 mM concentration of PDTC. Conclusion: PDTC at 1.0 mM concentration could have a significant pharmacological role in activating and enhancing odontogenic differentiation of dental stem cells and make it an important step in regenerative dentistry.
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Registered trials
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