ReviewGlobal medical genetics2024
Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors.
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Review in Global medical genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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2 citing papers in PubMed.
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124 authors.
Chunwei XuDepartment of Scientific Research, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou Zhejiang 310022, People's Republic of China.
Bin LianKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
Juanjuan OuDepartment of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Qian WangDepartment of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.
Wenxian WangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Ke WangNational Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi Jiangsu, People's Republic of China.
Dong WangDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Zhengbo SongDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Aijun LiuSenior Department of Pathology, the 7th Medical Center of PLA General Hospital, Beijing, People's Republic of China.
Jinpu YuDepartment of Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Wenzhao ZhongDepartment of Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou Guangdong, People's Republic of China.
Zhijie WangState Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Yongchang ZhangDepartment of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Jingjing LiuDepartment of Thoracic Cancer, Jilin Cancer Hospital, Changchun, Jilin, People's Republic of China.
Shirong ZhangDepartment of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou Zhejiang, People's Republic of China.
Xiuyu CaiDepartment of VIP Inpatient, Sun Yet-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China.
Anwen LiuDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Wen LiKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Lili MaoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
Ping ZhanDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Hongbing LiuDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Tangfeng LvDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Liyun MiaoDepartment of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Lingfeng MinDepartment of Respiratory Medicine, Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu, People's Republic of China.
Yu ChenDepartment of Medical Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
Jingping YuanDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Feng WangDepartment of Internal Medicine, Cancer Center of PLA, Qinhuai Medical Area, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Zhansheng JiangDerpartment of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Gen LinDepartment of Medical Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
Long HuangDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Xingxiang PuDepartment of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Rongbo LinDepartment of Medical Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
Weifeng LiuDepartment of Orthopaedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China.
Chuangzhou RaoDepartment of Radiotherapy and Chemotherapy, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, People's Republic of China.
Dongqing LvDepartment of Pulmonary Medicine, Taizhou Hospital of Wenzhou Medical University, Taizhou, Zhejiang, People's Republic of China.
Zongyang YuDepartment of Respiratory Medicine, the 900th Hospital of the Joint Logistics Team (the Former Fuzhou General Hospital), Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Xiaoyan LiDepartment of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Chuanhao TangDepartment of Medical Oncology, Peking University International Hospital, Beijing, People's Republic of China.
Chengzhi ZhouDepartment of State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University), Guangzhou Guangdong, People's Republic of China.
Junping ZhangDepartment of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan, Shanxi, People's Republic of China.
Junli XueDepartment of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Hui GuoDepartment of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Qian ChuDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Rui MengDepartment of Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, People's Republic of China.
Jingxun WuDepartment of Medical Oncology, the First Affiliated Hospital of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China.
Rui ZhangDepartment of Medical Oncology, Cancer Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
Jin ZhouDepartment of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology, Chengdu, Sichuan, People's Republic of China.
Zhengfei ZhuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Yongheng LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
Hong QiuDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Fan XiaDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Yuanyuan LuDepartment of State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an Shaanxi, People's Republic of China.
Xiaofeng ChenDepartment of Oncology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu, People's Republic of China.
Rui GeDepartment of General Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
Enyong DaiDepartment of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Yu HanDepartment of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Weiwei PanDepartment of Cell Biology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, People's Republic of China.
Fei PangDepartment of Medical, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China.
Jintao HuangDepartment of Medical, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China.
Kai WangDepartment of Medical, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China.
Fan WuDepartment of Medical, Menarini Silicon Biosystems Spa, Shanghai, People's Republic of China.
Bingwei XuDepartment of Biotherapy, Cancer Institute, First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.
Liping WangDepartment of Oncology, Baotou Cancer Hospital, Baotou Inner Mongolia, People's Republic of China.
Youcai ZhuDepartment of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of China.
Li LinDepartment of Medical Oncology, Peking University International Hospital, Beijing, People's Republic of China.
Yanru XieDepartment of Oncology, Lishui Municipal Central Hospital, Lishui, Zhejiang, People's Republic of China.
Xinqing LinDepartment of State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University), Guangzhou Guangdong, People's Republic of China.
Jing CaiDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Ling XuDepartment of Interventional Pulmonary Diseases, Anhui Chest Hospital, Hefei, Anhui, People's Republic of China.
Jisheng LiDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Xiaodong JiaoDepartment of Medical Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China.
Kainan LiDepartment of Oncology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Jia WeiDepartment of the Comprehensive Cancer Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Huijing FengDepartment of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan, Shanxi, People's Republic of China.
Lin WangDepartment of Pathology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan, Shanxi, People's Republic of China.
Yingying DuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Wang YaoDepartment of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Xuefei ShiDepartment of Respiratory Medicine, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, People's Republic of China.
Xiaomin NiuDepartment of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Dongmei YuanDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Yanwen YaoDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Jianhui HuangDepartment of Oncology, Lishui Municipal Central Hospital, Lishui, Zhejiang, People's Republic of China.
Yue FengDepartment of Gynecologic Radiation Oncology, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Yinbin ZhangDepartment of Oncology, the Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Pingli SunDepartment of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Hong WangSenior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing, People's Republic of China.
Mingxiang YeDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Zhaofeng WangDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Yue HaoDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Zhen WangDepartment of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Bin WanDepartment of Respiratory Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Donglai LvDepartment of Clinical Oncology, the 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei, Anhui, People's Republic of China.
Zhanqiang ZhaiDepartment of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of China.
Shengjie YangDepartment of Thoracic Surgery, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong, Yunnan, People's Republic of China.
Jing KangDepartment of Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou Guangdong, People's Republic of China.
Jiatao ZhangDepartment of Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou Guangdong, People's Republic of China.
Chao ZhangDepartment of Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou Guangdong, People's Republic of China.
Lin ShiDepartment of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Yina WangDepartment of Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Bihui LiDepartment of Oncology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People's Republic of China.
Zhang ZhangDepartment of International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, Guangdong, People's Republic of China.
Zhongwu LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
Zhefeng LiuSenior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing, People's Republic of China.
Nong YangDepartment of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Lin WuDepartment of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Huijuan WangDepartment of Internal Medicine, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, , People's Republic of China.
Gu JinDepartment of Bone and Soft-tissue Surgery, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Guansong WangDepartment of Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Jiandong WangDepartment of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Meiyu FangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Yong FangDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Yuan LiDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Xiaojia WangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Jing ChenDepartment of Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, People's Republic of China.
Yiping ZhangDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China.
Xixu ZhuDepartment of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Yi ShenDepartment of Thoracic Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Shenglin MaDepartment of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Biyun WangDepartment of Breast Cancer and Urological Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Lu SiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.
Yuanzhi LuDepartment of Clinical Pathology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People's Republic of China.
Ziming LiDepartment of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Wenfeng FangDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China.
Yong SongDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair. However, FGFR gene mutations, including amplification, fusion, and mutation, can disrupt epigenetics, transcriptional regulation, and tumor microenvironment interactions, leading to cancer development. Targeting these kinase mutations with small molecule drugs or antibodies has shown clinical benefits. For example, erdafitinib is approved for treating locally advanced or metastatic urothelial cancer patients with FGFR2/FGFR3 mutations, and pemigatinib is approved for treating cholangiocarcinoma with FGFR2 fusion/rearrangement. Effective screening of FGFR variant patients is crucial for the clinical application of FGFR inhibitors. Various detection methods, such as polymerase chain reaction, next-generation sequencing, fluorescence in situ hybridization, and immunohistochemistry, are available, and their selection should be based on diagnostic and treatment decision-making needs. Our developed expert consensus aims to standardize the diagnosis and treatment process for FGFR gene mutations and facilitate the practical application of FGFR inhibitors in clinical practice.
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precision medicinesolid tumorstargeted therapytyrosine receptor kinase
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