Evidence map›Paper›PMID 39583105›Full record

SynthesisPeerJ2024

The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review.

Muhamad Alojid Anis Amiera, Tuan Noorkorina Tuan Kub, Azian Harun, Rohimah Mohamud, Nur Rina Alissa Razian, Yasmin Khairani Muhammad Ismadi, Wan Alif Syazwani Wan Alias, Mohammed Hussain Abdulrazak, Ernawati Teni

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhamad Alojid Anis AmieraDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Tuan Noorkorina Tuan KubDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Azian HarunDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Rohimah MohamudDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Nur Rina Alissa RazianDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Yasmin Khairani Muhammad IsmadiDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0002-2059-821X
Wan Alif Syazwani Wan AliasDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Mohammed Hussain AbdulrazakDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Ernawati TeniNational Research and Innovation Agency (BRIN), Research Centre for Pharmaceutical Ingredients and Traditional Medicines, Yogjakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To critically analyse literature on the anticancer properties of andrographolide in Method: This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from Result: Out of 93 articles, six were relevant, primarily focusing on Conclusion: These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.

Indexed as

ApoptosisCell ProliferationDiterpenesStomach NeoplasmsAndrographisAntineoplastic AgentsAntineoplastic Agents, PhytogenicCell CycleCell Line, TumorHumansOxidative StressandrographolideAntineoplastic AgentsAntineoplastic Agents, PhytogenicDiterpenesAndrographis paniculataAndrographolideAnticancerGastric cancer cell linesIn vitro

Identifiers

PMID39583105
PMCPMC11585289

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.