ArticleNeuropsychiatric disease and treatment2024
Associations Between Thyroid Hormones Levels and Gray Matter Volume of Frontal Lobe Involved into Violence in Male Schizophrenia Patients.
Article in Neuropsychiatric disease and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association between thyroid hormone T3 and aggression in drug-naïve schizophrenia: a directed acyclic graph analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between free thyroxine and aggression: the chain mediating role of hostile attribution bias and psychological resilience.Frontiers in psychology · 2026Article
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Authors and funding
4 authors.
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Abstract
Background: Thyroid dysfunction and frontal lobe gray matter volume (GMV) alterations are associated with violence in schizophrenia (SCZ); however, little is known about the relationship between thyroid dysfunction and frontal lobe GMV. This study aimed to evaluate whether thyroid hormone levels were associated with frontal lobe GMV in male patients with schizophrenia and violence. Methods: Fifty-five male patients with SCZ underwent triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) tests and structural magnetic resonance imaging (sMRI) scans. The sMRI data were processed using the FreeSurfer version 5.0. Multiple linear stepwise regression analysis was used to investigate the relationship between frontal lobe GMV and thyroid hormone levels in all patients. Results: Patients with SCZ and violence exhibited lower GMV of the left frontal pole and higher TSH levels than those without violence. After controlling for potential covariates, the frontal pole GMV was negatively associated with TSH levels in all participants. Conclusion: These findings expand our understanding of the influence of TSH on frontal pole GMV in patients with schizophrenia and violence.
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