Evidence map›Paper›PMID 39582918›Full record

ArticleInternational journal of general medicine2024

Investigating Clinical Factors Influencing Pulmonary Fibrosis in Acute Diquat Poisoning.

Meili Xu, Hongliu Chen, Jianjing Chen, Rongzong Ye, Huan Xiao, Jingwen Li, Chaoqian Li

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Article in International journal of general medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Meili XuDepartment of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Hongliu ChenDepartment of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Jianjing ChenDepartment of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Rongzong YeGuangxi Medical University, Nanning, Guangxi, People's Republic of China.
Huan XiaoDepartment of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Jingwen LiGuangxi Medical University, Nanning, Guangxi, People's Republic of China.
Chaoqian LiDepartment of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.ORCID 0000-0002-0916-3661

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to explore the factors influencing pulmonary fibrosis in patients with acute diquat poisoning through logistic regression analysis. Methods: A retrospective analysis was conducted on 68 cases of acute diquat poisoning due to suicidal intent admitted to our hospital from February 2020 to March 2023. Patients were divided into a combined group (28 cases with pulmonary fibrosis) and an acute diquat poisoning group (40 cases without). A healthy control group consisted of 40 individuals. General data were compared among the three groups, and laboratory indicators were analyzed. Single and multiple logistic regression analyses were performed to identify risk factors for pulmonary fibrosis. Results: There were no significant differences in gender, age, BMI, poisoning status, or treatment timing among the groups (P > 0.05). The combined group had significantly higher diquat ingestion dose, SIRS score, SOFA score, and APACHE II score compared to the poisoning group (P < 0.05). In the acute poisoning group, these scores were also higher than in the healthy controls (P < 0.05). Laboratory indicators, including Hb, PLT, ALP, DBil, ALB, BUN, Glu, BNP, and pH, showed no significant differences (P > 0.05). However, WBC, ALT, TBil, DBil, Cr, K+, Tn I, and Lac levels were significantly higher in the combined group compared to the acute poisoning group (P < 0.05). Logistic regression analysis identified factors influencing pulmonary fibrosis as diquat ingestion dose, K+, ALT, PaO2, Lac, and HCO3-. Conclusion: The factors influencing pulmonary fibrosis in acute diquat poisoning include diquat ingestion dose, K+, ALT, PaO2, Lac, and HCO3-. These findings enhance understanding of pulmonary fibrosis pathogenesis and may inform clinical management for affected patients.

Indexed as

acute diquat poisoningALTK+PaO2pulmonary fibrosis

Identifiers

PMID39582918
PMCPMC11585977

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