Evidence map›Paper›PMID 39582889›Full record

ArticleComputational and structural biotechnology journal2024

Cell-to-cell distance that combines gene expression and gene embeddings.

Fangfang Guo, Dailin Gan, Jun Li

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fangfang GuoDepartment of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA.
Dailin GanDepartment of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA.
Jun LiDepartment of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA.

Funding

CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to boneR01CA252878 · NCI · UNIVERSITY OF NOTRE DAME · PI LITTLEPAGE, LAURIE E. · 2021 to 2025
$1.8M
Immunosuppression and Metabolic Rewiring in Tumor-infiltrating NeutrophilsR01CA280097 · NCI · UNIVERSITY OF NOTRE DAME · PI Xin Lu · 2023 to 2026
$1.4M
NCI NIH HHS R01 CA252878NCI NIH HHS R01 CA280097
6 · The paper itself

Abstract

The application of large-language models (LLMs) to single-cell gene-expression data has introduced a new type of data that includes a gene-embedding matrix, in addition to the experimentally obtained gene-expression matrix. This paper addresses a fundamental problem in analyzing such data: how to effectively combine the information from both matrices to better define cell-to-cell distance. We identify a computationally feasible solution that demonstrates superior ability to cluster cells of the same type across all six real datasets we tested, underscoring its advantage as a measure of cell-to-cell distance.

Identifiers

PMID39582889
PMCPMC11584677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.