ArticleCerebral cortex (New York, N.Y. : 1991)2024
Temporal complexity of the BOLD-signal in preterm versus term infants.
Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex.Nature communications · 2026Article
- Early Life Resting-State Network Functional Connectivity and Long-Term Neurodevelopmental Outcomes after Neonatal Encephalopathy.AJNR. American journal of neuroradiology · 2026Article
- Altered Functional Network Energy Across Multiscale Brain Networks in Preterm vs. Full-Term Subjects: Insights from the Adolescent Brain Cognitive Development (ABCD) Study.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Development of brain metastable dynamics during the equivalent of the third gestational trimester.Developmental cognitive neuroscience · 2025Review
- Altered Functional Network Energy Across Multiscale Brain Networks in Preterm vs. Full-Term Subjects: Insights from the Adolescent Brain Cognitive Development (ABCD) Study.bioRxiv : the preprint server for biology · 2025Article
- Does the brain's E:I balance really shape long-range temporal correlations? Lessons learned from 3T MRI.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
4 authors.
Funding
Abstract
Preterm birth causes alterations in structural and functional cerebral development that are not fully understood. Here, we investigate whether basic characteristics of BOLD signal itself might differ across preterm, term equivalent, and term infants. Anatomical, fMRI, and diffusion weighted imaging data from 716 neonates born at 23-43 weeks gestational age were obtained from the Developing Human Connectome Project. Hurst exponent (H; a measure of temporal complexity of a time-series) was computed from the power spectral density of the BOLD signal within 13 resting state networks. Using linear mixed effects models to account for scan age and birth age, we found that H increased with age, that earlier birth age contributed to lower H values, and that H increased most in motor and sensory networks. We then tested for a relationship between temporal complexity and structural development using H and DTI-based estimates of myelination and found moderate but significant correlations. These findings suggest that the temporal complexity of BOLD signal in neonates relates to age and tracks with known developmental trajectories in the brain. Elucidating how these signal-based differences might relate to maturing hemodynamics in the preterm brain could yield new information about neurophysiological vulnerabilities during this crucial developmental period.
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