Evidence map›Paper›PMID 39582236›Full record

ArticleACS chemical neuroscience2024

Effect of a SARS-CoV-2 Protein Fragment on the Amyloidogenic Propensity of Human Islet Amyloid Polypeptide.

Marvin Bilog, Jennifer Cersosimo, Iliana Vigil, Ruel Z B Desamero, Adam A Profit

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marvin BilogPhD Programs in Chemistry and Biochemistry, the Graduate Center of the City University of New York, New York, New York 10016, United States.
Jennifer CersosimoPhD Programs in Chemistry and Biochemistry, the Graduate Center of the City University of New York, New York, New York 10016, United States.
Iliana VigilDepartment of Chemistry, York College of the City University of New York, Jamaica, New York 11451, United States.
Ruel Z B DesameroPhD Programs in Chemistry and Biochemistry, the Graduate Center of the City University of New York, New York, New York 10016, United States.ORCID 0000-0001-5471-2335
Adam A ProfitPhD Programs in Chemistry and Biochemistry, the Graduate Center of the City University of New York, New York, New York 10016, United States.

Funding

Probing the role of helix-1 in amyloid formation by serum amyloid AR15GM119040 · NIGMS · YORK COLLEGE · PI DESAMERO, RUEL Z B, PROFIT, ADAM A · 2016 to 2016
$493k
Helical Peptoids as Potential Amylin Aggregation InhibitorsR15GM134491 · NIGMS · YORK COLLEGE · PI PROFIT, ADAM A · 2019 to 2019
$491k
NIGMS NIH HHS R15 GM119040NIGMS NIH HHS R15 GM134491
6 · The paper itself

Abstract

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the onset of COVID-19 have been linked to an increased risk of developing type 2 diabetes. While a variety of mechanisms may ultimately be responsible for the onset of type 2 diabetes under these circumstances, one mechanism that has been postulated involves the increased aggregation of human islet amyloid polypeptide (hIAPP) through direct interaction with SARS-CoV-2 viral proteins. Previous computational studies investigating this possibility revealed that a nine-residue peptide fragment known as SK9 (SFYVYSRVK) from the SARS-CoV-2 envelope protein can stabilize the native conformation of hIAPP

Indexed as

COVID-19Islet Amyloid PolypeptideMolecular Dynamics SimulationSARS-CoV-2AmyloidDiabetes Mellitus, Type 2HumansMolecular Docking SimulationPeptide FragmentsAmyloidIslet Amyloid PolypeptidePeptide Fragmentsaggregationamyloid fibril formationbiophysical assaysdockinghuman islet amyloid polypeptidemolecular dynamic simulationSARS-CoV-2 peptides

Identifiers

PMID39582236
PMCPMC11660541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.