Evidence map›Paper›PMID 39582109›Full record

ArticleGut microbes

Cerebrovascular damage caused by the gut microbe/host co-metabolite

Sita N Shah, Tobias B-A Knausenberger, Matthew G Pontifex, Emily Connell, Gwénaëlle Le Gall, Tom A J Hardy, David W Randall, Kieran McCafferty, Muhammad M Yaqoob, Egle Solito and 6 more

Abstract read
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In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  8. Article
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  13. Can bacteria control the human brain?Communicative & integrative biology · 2026
    Review
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  15. Article
  16. ACS pharmacology & translational science · 2025
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sita N ShahBlizard Institute, Faculty of Medicine & Dentistry, Queen Mary, University of London, London, UK.
Tobias B-A KnausenbergerBlizard Institute, Faculty of Medicine & Dentistry, Queen Mary, University of London, London, UK.
Matthew G PontifexNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich, UK.ORCID 0000-0003-2174-2313
Emily ConnellNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich, UK.
Gwénaëlle Le GallNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich, UK.ORCID 0000-0002-1379-2196
Tom A J HardyBlizard Institute, Faculty of Medicine & Dentistry, Queen Mary, University of London, London, UK.
David W RandallDepartment of Renal Medicine and Transplantation, Royal London Hospital, Barts Health NHS Trust, London, UK.
Kieran McCaffertyDepartment of Renal Medicine and Transplantation, Royal London Hospital, Barts Health NHS Trust, London, UK.
Muhammad M YaqoobDepartment of Renal Medicine and Transplantation, Royal London Hospital, Barts Health NHS Trust, London, UK.
Egle SolitoWilliam Harvey Research Institute, Faculty of Medicine & Dentistry, Queen Mary, University of London, London, UK.
Michael MüllerNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich, UK.
Andrew V StachulskiRobert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool, UK.
Robert C GlenFaculty of Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
David VauzourNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich, UK.ORCID 0000-0001-5952-8756
Lesley HoylesCentre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Clifton, Nottingham, UK.ORCID 0000-0002-6418-342X
Simon McArthurInstitute of Dentistry, Faculty of Medicine & Dentistry, Queen Mary, University of London, London, UK.ORCID 0000-0001-8521-1808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence indicates the involvement of gut microbe-derived metabolites. Circulating levels of the gut microbe/host co-metabolite

Indexed as

Blood-Brain BarrierCresolsErbB ReceptorsGastrointestinal MicrobiomeSulfuric Acid EstersAnimalsBrainCerebrovascular DisordersEndothelial CellsHumansMaleMiceMice, Inbred C57BLRenal Insufficiency, ChronicSignal Transduction4-cresol sulfateCresolsErbB ReceptorsSulfuric Acid EstersBlood-brain barriercerebrovascular diseasechronic kidney diseasegut microbiotap-cresol sulfate

Identifiers

PMID39582109
PMCPMC11591591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.