Evidence map›Paper›PMID 39582088›Full record

ArticleScientific reports2024

Sensory neuron LKB1 mediates ovarian and reproductive function.

Melissa E Lenert, Emily K Debner, Michael D Burton

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Melissa E LenertNeuroimmunology and Behavior Laboratory, Department of Neuroscience, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies (CAPS), The University of Texas at Dallas, Richardson, TX, 75080, USA.ORCID 0000-0002-5504-4700
Emily K DebnerNeuroimmunology and Behavior Laboratory, Department of Neuroscience, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies (CAPS), The University of Texas at Dallas, Richardson, TX, 75080, USA.ORCID 0000-0002-2551-912X
Michael D BurtonNeuroimmunology and Behavior Laboratory, Department of Neuroscience, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies (CAPS), The University of Texas at Dallas, Richardson, TX, 75080, USA. michael.burton@utdallas.edu.ORCID 0000-0002-0628-824X

Funding

Mechanisms involved in postoperative recovery: a focus on pain, delirium, and neuroinflammationR35GM147094 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Michael D Burton · 2022 to 2026
$1.9M
The role of cell-specific TLR4 in Diabetic Peripheral NeuropathyR21DK130015 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI BURTON, MICHAEL D · 2022 to 2024
$577k
Identification of Sex Differences in Monocytes and Metabolism in the Maintenance of Chronic Muscle PainK00HD118378 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Melissa Elizabeth Lenert · 2024 to 2026
$283k
Identification of Sex Differences in Monocytes and Metabolism in the Maintenance of Chronic Muscle PainF99NS129173 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI LENERT, MELISSA ELIZABETH · 2022 to 2023
$89k
NICHD NIH HHS K00 HD118378NIDDK NIH HHS DK130015NIDDK NIH HHS R21 DK130015NIGMS NIH HHS GM147094NIGMS NIH HHS R35 GM147094NINDS NIH HHS F99 NS129173NINDS NIH HHS F99NS129173Rita Allen Foundation Pain Scholar
6 · The paper itself

Abstract

Treatments for reproductive disorders in women consist of hormone replacement therapy, which have negative side effects that impact health, spurring the need to understand new mechanisms to employ new therapeutic strategies. Bidirectional communication between sensory neurons and the organs they innervate is an emerging area of interest in tissue physiology with a relevance in reproductive disorders. We hypothesized that the metabolic activity of sensory neurons has a profound effect on reproductive phenotypes. To investigate this phenomenon, we utilized a murine model with conditional deletion of liver kinase B1 (LKB1), a serine/threonine kinase that regulates cellular metabolism in sensory neurons (Na

Indexed as

AMP-Activated Protein KinasesOvaryProtein Serine-Threonine KinasesReproductionSensory Receptor CellsAnimalsFemaleFertilityGanglia, SpinalMaleMiceMice, KnockoutAMP-Activated Protein KinasesProtein Serine-Threonine KinasesStk11 protein, mouseFemaleFertilityLKB1Nav1.8Sensory neuron

Identifiers

PMID39582088
PMCPMC11586444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.