Evidence map›Paper›PMID 39582030›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025

Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections.

Zhaoyuan Tu, Yao Ma, Huiping Shang, Sha Zhao, Bao Xue, Yu Qu, Jiangfan Chen, Yulong Li, Ji Hu, Fang Gao and 3 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dissociable control of depression and visceral pain by the pICNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. An Amygdala-hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhaoyuan Tu *Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.
Yao Ma *Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.
Huiping ShangChinese Institute for Brain Research (CIBR), Beijing, China.
Sha ZhaoNeuropsychiatry Research Institute, The Affiliated Hospital of Qingdao University, Qingdao, China.
Bao XueNeuropsychiatry Research Institute, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yu QuNeuropsychiatry Research Institute, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jiangfan ChenMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.ORCID http://orcid.org/0000-0002-0446-3956
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-9166-9919
Ji HuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-7930-2316
Fang GaoDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Huamin XuNeuropsychiatry Research Institute, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xufeng XuNeuropsychiatry Research Institute, The Affiliated Hospital of Qingdao University, Qingdao, China. xuxufeng@qdu.edu.cn.
Xia ZhangMental Health Center, West China Hospital of Sichuan University, Chengdu, China. Xia.Zhang@qdu.edu.cn.

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0203002National Natural Science Foundation of China (National Science Foundation of China) 32000788National Natural Science Foundation of China (National Science Foundation of China) 32371187National Natural Science Foundation of China (National Science Foundation of China) 81830035National Natural Science Foundation of China (National Science Foundation of China) 82090033Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2019ZD35Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2024MH063
6 · The paper itself

Abstract

Up to 45% of patients surviving from transient global cerebral ischemia (GCI) after cardiac arrest develop post-global cerebral ischemia depression (PGCID), but how to treat PGCID is clinically unknown. Here we find that cannabinoid type-1 receptor (CB

Indexed as

AmygdalaBasolateral Nuclear ComplexBrain IschemiaDepressionEndocannabinoidsPrefrontal CortexAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutNeural PathwaysReceptor, Cannabinoid, CB1Stress, PsychologicalEndocannabinoidsReceptor, Cannabinoid, CB1

Identifiers

PMID39582030
PMCPMC12089379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.