Evidence map›Paper›PMID 39582018›Full record

ArticleScientific reports2024

Stress hyperglycemia ratio association with all-cause mortality in critically ill patients with coronary heart disease: an analysis of the MIMIC-IV database.

Xiaofang Chen, Zewen Yang, Rui Shi, Xiaoyan Wang, Xuhua Li

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

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21citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xiaofang ChenDepartment of Cardiology, University Hospital, Zhejiang Normal University, Jinhua, 321000, Zhejiang, China.
Zewen YangDepartment of Cardiology, Yiwu Central Hospital, Yiwu, 322000, Zhejiang, China.
Rui ShiDepartment of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 51000, China.
Xiaoyan WangDepartment of Cardiology, University Hospital, Zhejiang Normal University, Jinhua, 321000, Zhejiang, China.
Xuhua LiDepartment of Internal Medicine, University Hospital, Zhejiang Normal University, 688 Yingbin Avenue, Jinhua, 321000, Zhejiang, China. 20225112@zjnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The stress hyperglycemia ratio (SHR) indicates relative hyperglycemia levels. Research on the impact of SHR on mortality in coronary heart disease (CHD) patients in intensive care is limited. This study explores the predictive accuracy of SHR for the prognosis of CHD patients in the ICU. Methods This study included 2,059 CHD patients from the American Medical Information Mart for Intensive Care (MIMIC-IV) database. SHR was determined using the formula: SHR = (admission glucose) (mmol/L) / (1.59 * HbA1c [%] - 2.59). Subjects were stratified into quartiles based on SHR levels to examine the correlation between SHR and in-hospital mortality. The restricted cubic splines and Cox proportional hazards models were employed to assess this association, while Kaplan-Meier survival analysis was executed to ascertain the mortality rates across the SHR quartiles. Results Among the 2059 participants (1358 men), the rates of in-hospital and ICU mortality were 8.5% and 5.25%, respectively. Analysis showed SHR as a significant predictor of increased risk for both in-hospital (HR,1.16, 95% CI: 1.02-1.32, P = 0.022) and ICU mortality (HR, 1.16, 95% CI: 1.01-1.35, P = 0.040) after adjustments. A J-shaped relationship was noted between SHR and mortality risks (p for non-linearity = 0.002, respectively). Kaplan-Meier analysis confirmed substantial differences in in-hospital and ICU mortality across SHR quartiles. Conclusions SHR significantly predicts in-hospital and ICU mortality in critically ill CHD patients, indicating that higher SHR levels correlate with longer ICU stays and increased mortality. This underscores the potential of SHR as a prognostic marker for ICU CHD patients.

Indexed as

Coronary DiseaseCritical IllnessHospital MortalityHyperglycemiaAgedBlood GlucoseDatabases, FactualFemaleHumansIntensive Care UnitsKaplan-Meier EstimateMaleMiddle AgedPrognosisProportional Hazards ModelsBlood GlucoseCoronary heart diseaseMIMIC-IV databaseMortalityStress hyperglycemia ratio

Identifiers

PMID39582018
PMCPMC11586423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.