Evidence map›Paper›PMID 39581914›Full record

ArticlePediatric cardiology2025

The Role of Nt-Pro-Bnp in Predicting Outcome in Pediatric Hypertrophic Cardiomyopathy.

Nicoletta Cantarutti, Rachele Adorisio, Sara Di Marzio, Marianna Cicenia, Irma Battipaglia, Erica Mencarelli, Massimo Stefano Silvetti, Antonio Amodeo, Fabrizio Drago

Abstract read
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In one paragraph

Article in Pediatric cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicoletta CantaruttiPediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Bambino Gesù Children's Hospital, IRCCS, Via Della Torre Di Palidoro, 00054, Fiumicino, RM, Italy.
Rachele AdorisioHeart Failure and Transplant, Mechanical Circulatory Support Unit, Bambino Gesù Children's Hospital, IRCCS, Piazzale Sant'Onofrio 4, 00165, Rome, Italy. rachele.adorisio@opbg.net.
Sara Di MarzioPediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Bambino Gesù Children's Hospital, IRCCS, Via Della Torre Di Palidoro, 00054, Fiumicino, RM, Italy.
Marianna CiceniaPediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Bambino Gesù Children's Hospital, IRCCS, Via Della Torre Di Palidoro, 00054, Fiumicino, RM, Italy.
Irma BattipagliaPediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Bambino Gesù Children's Hospital, IRCCS, Via Della Torre Di Palidoro, 00054, Fiumicino, RM, Italy.
Erica MencarelliHeart Failure and Transplant, Mechanical Circulatory Support Unit, Bambino Gesù Children's Hospital, IRCCS, Piazzale Sant'Onofrio 4, 00165, Rome, Italy.
Massimo Stefano SilvettiPediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Bambino Gesù Children's Hospital, IRCCS, Via Della Torre Di Palidoro, 00054, Fiumicino, RM, Italy.
Antonio AmodeoHeart Failure and Transplant, Mechanical Circulatory Support Unit, Bambino Gesù Children's Hospital, IRCCS, Piazzale Sant'Onofrio 4, 00165, Rome, Italy.
Fabrizio DragoPediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Bambino Gesù Children's Hospital, IRCCS, Via Della Torre Di Palidoro, 00054, Fiumicino, RM, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

hypothesisThe aim of the study was to evaluate the correlation between NTproBNP and left ventricular mass (LVM) in children affected by hypertrophic cardiomyopathy (HCM), both asymptomatic, symptomatic, and with implantable cardioverter-defibrillator (ICD).

methodsA total of 225 pediatric patients were evaluated and 45 were enrolled in the study because met inclusion criteria (age < 18 years; diagnosis of hypertrophic cardiomyopathy; NTproBNP > 600 pg/ml).

resultsThe analysis showed a significant correlation between NTproBNP level and LVM (p = 0.024). ANOVA test showed that high level of NTproBNP and LVM were significantly correlated to ICD implantation (p = 0.001; p = 0.003). Multivariate analysis showed NTproBNP as an independent risk factor for ICD implantation (p = 0.035).

conclusionOur study showed that NTproBNP levels directly correlated to LVM and disease progression and it was found to be predictive, together with LVM, of ICD implantation.

Indexed as

Cardiomyopathy, HypertrophicNatriuretic Peptide, BrainPeptide FragmentsAdolescentBiomarkersChildChild, PreschoolDefibrillators, ImplantableDisease ProgressionFemaleHeart VentriclesHumansInfantMalePredictive Value of TestsPrognosisBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Hypertrophic cardiomyopathyNTproBNPOutcomePediatricRisk stratification

Identifiers

PMID39581914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.