Evidence map›Paper›PMID 39581901›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Home-based, computer-assisted cognitive rehabilitation for attention in pediatric onset multiple sclerosis: a randomized, multicenter pilot study.

Camilla Masciulli, E Portaccio, B Goretti, C Niccolai, M Simone, R G Viterbo, M Zaffaroni, L Pippolo, E Cocco, G Fenu and 14 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Combined cognitive rehabilitation and neurofeedback therapy: effects on executive function and cognitive flexibility in people with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Camilla MasciulliDepartment of NEUROFARBA, University of Florence, Largo Piero Palagi, 1, Florence, 50139, Italy. camilla.masciulli@unifi.it.ORCID http://orcid.org/0009-0008-6419-5704
E PortaccioDepartment of NEUROFARBA, University of Florence, Largo Piero Palagi, 1, Florence, 50139, Italy.
B GorettiDepartment of NEUROFARBA, University of Florence, Largo Piero Palagi, 1, Florence, 50139, Italy.
C NiccolaiIRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
M SimoneDepartment of Precision and Regenerative Medicine and Jonic Area, Child Neuropsychiatry Unit, University 'Aldo Moro' of Bari, Bari, Italy.
R G ViterboUSVD neuropsichiatra infantile asl Bari, Bari, Italy.
M ZaffaroniNeuroimmunology Unit - Multiple Sclerosis Center, Hospital of Gallarate, ASST della Valle Olona, Gallarate, Italy.
L PippoloNeuroimmunology Unit - Multiple Sclerosis Center, Hospital of Gallarate, ASST della Valle Olona, Gallarate, Italy.
E CoccoMultiple Sclerosis Centre, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
G FenuMultiple Sclerosis Centre, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
E CartaMultiple Sclerosis Centre, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
M FalautanoSan Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
C CelicoSan Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
M PardiniDepartment of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
G L MancardiDepartment of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
R GuerriniPaediatric Neurology Unit and Laboratories, Neuroscience Department, Meyer Childrens Hospital IRCCS, Florence, Italy.
F MelaniPaediatric Neurology Unit and Laboratories, Neuroscience Department, Meyer Childrens Hospital IRCCS, Florence, Italy.
F GiovannelliDepartment of NEUROFARBA, University of Florence, Largo Piero Palagi, 1, Florence, 50139, Italy.
M RoccaSan Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
P IaffaldanoDepartment of Translational Biomedicine and Neuroscience, DiBraiN, University of Bari Aldo Moro, Bari, Italy.
A TacchinoScientific Research Area, Italian Multiple Sclerosis Foundation, Genoa, Italy.
P ZaratinMultiple Sclerosis International Federation (MSIF), London, UK.
M FilippiSan Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
M P AmatoDepartment of NEUROFARBA, University of Florence, Largo Piero Palagi, 1, Florence, 50139, Italy.

Funding

Fondazione Italiana Sclerosi Multipla Fondazione Italiana Sclerosi Multipla
6 · The paper itself

Abstract

objectiveCognitive impairment affects approximately 30% of pediatric onset Multiple Sclerosis (POMS) patients with a negative impact on everyday life. The aim of this study was to evaluate the feasibility and effectiveness of a home-based, computer-assisted training of attention in patients with POMS.

methodsThis was a randomized double-blind study. Subjects were randomized to specific training (ST) or non-specific training (n-ST), delivered through a customized module based on attention exercises (COGNI-TRAcK2). The main feature of the ST is the implementation of working load algorithms and procedures for intensiveness regulation. The effectiveness of the ST on attention was primarily assessed on the Symbol Digit Modalities Test (SDMT), using the Wilcoxon signed-rank test. Secondary objectives included effectiveness on other cognitive tests. The evaluations were performed at baseline, end of training and 3-month follow-up.

results22 relapsing-remitting patients were included: data of 8 subjects in n-ST and 5 subjects in ST were available. As for the primary outcome, SDMT score improved in the ST group (from 31.2 at baseline to 42.4 after 3 months, p = 0.043). There was no benefit in other neuropsychological measures.

conclusionsThese preliminary findings point to a potential benefit of a home-based, computer-assisted training of attention in patients with POMS.

Indexed as

AttentionCognitive Behavioral TherapyCognitive DysfunctionMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingTherapy, Computer-AssistedAdolescentChildCognitive TrainingDouble-Blind MethodFemaleHumansMaleNeuropsychological TestsPilot ProjectsTreatment OutcomeAdolescentChildCognitive dysfunctionCognitive trainingMultiple sclerosisNeuropsychological tests

Identifiers

PMID39581901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.