Evidence map›Paper›PMID 39581700›Full record

ArticleHLA2024

NKG2C Sequence Polymorphism Modulates the Expansion of Adaptive NK Cells in Response to Human CMV.

Judit Asenjo, Manuela Moraru, Karima Al-Akioui-Sanz, Mireia Altadill, Aura Muntasell, Miguel López-Botet, Carlos Vilches

Abstract read
In one paragraph

Article in HLA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The CD94/NKG2A-HLA-E Axis as a Target in Cancer Immunotherapy: A Critical Perspective.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  2. Review
  3. NK Cells: A Powerful Squad Versus SARS-CoV-2.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Judit AsenjoImmunogenetics & Histocompatibility Lab, Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana, Majadahonda, Spain.ORCID 0000-0001-6015-4755
Manuela MoraruImmunogenetics & Histocompatibility Lab, Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana, Majadahonda, Spain.
Karima Al-Akioui-SanzImmunogenetics & Histocompatibility Lab, Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana, Majadahonda, Spain.
Mireia AltadillUniversity Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-3118-8654
Aura MuntasellHospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Miguel López-BotetUniversity Pompeu Fabra, Barcelona, Spain.ORCID 0000-0003-4882-065X
Carlos VilchesImmunogenetics & Histocompatibility Lab, Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana, Majadahonda, Spain.ORCID 0000-0002-0300-9225

Funding

AEI/FEDER, EU PID2019-110609RB-C22/AEI/10.13039/501100011033Asociación Española contra el Cáncer Foundation GCB15152947MELEConsejería de Educación, Juventud y Deporte de la Comunidad de MadridEU FP7-MINECO Infect-ERA program (PCIN-2015-191-C02-01/02)EU Youth Employment Initiative, European Social Fund PEJ-2017-AI/BMD-7377
6 · The paper itself

Abstract

A subpopulation of NK cells with distinctive phenotype and function differentiates and expands specifically in response to infection by human cytomegalovirus (HCMV). A hallmark of these adaptive NK cells is their increased expression levels of the activating CD94/NKG2C receptor for HLA-E, and lack of expression of its inhibitory homologue CD94/NKG2A. Their frequency is highly variable in HCMV

Indexed as

AllelesCytomegalovirusCytomegalovirus InfectionsKiller Cells, NaturalNK Cell Lectin-Like Receptor Subfamily CPolymorphism, Genetic3' Untranslated RegionsAdaptive ImmunityGene FrequencyHLA-E AntigensHumansPromoter Regions, Genetic3' Untranslated RegionsHLA-E AntigensKLRC2 protein, humanNK Cell Lectin-Like Receptor Subfamily Callelescytomegalovirusgenetic polymorphismhuman geneticsnatural killer cell lectin‐like receptorsNKG2C receptor

Identifiers

PMID39581700
PMCPMC11586157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.