ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2025
Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report.
Abstract read
In one paragraph
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- A new era of precision diagnosis and treatment for lung cancer: artificial intelligence-driven multimodal data integration and clinical applications.Cell death & disease · 2026Review
- Development and validation of a 5mC-based prognostic model for lung adenocarcinoma survival.Cell reports. Medicine · 2026Article
- Lung cancer in non-smoking women (LCINSW): from risk factors to precision therapy.Cancer metastasis reviews · 2025Review
- Prognostic stratification through smoking status and cumulative smoking dose in advanced non-small cell lung cancer immunotherapy: a dose-dependent real-world analysis.Frontiers in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
152 authors.
Batel BlechterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland. Electronic address: batel.blechter@nih.gov.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Xiaoyu WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Haoyu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Wei Jie SeowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Hee Nam KimDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Maria Pik WongDepartment of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong.
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jason Y Y WongEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, Maryland.
Juncheng DaiDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
H Dean HosgoodDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Jiyeon ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Jiucun WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Minsun SongDepartment of Statistics and Research Institute of Natural Sciences, Sookmyung Women's University, Seoul, Republic of Korea.
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Jin Hee KimDepartment of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Baosen ZhouDepartment of Clinical Epidemiology and Center of Evidence Based Medicine, The First Hospital of China Medical University, Shenyang, People's Republic of China.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Min-Ho ShinDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Lap Ping ChungDepartment of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong.
She-Juan AnGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Hong ZhengDepartment of Epidemiology and Biostatistics, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
Yasushi YatabeDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Xu-Chao ZhangGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Young Tae KimCancer Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Young-Chul KimLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasuneup, Republic of Korea.
Roel C H VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
Bryan A BassigSaville Cancer Screening and Prevention Center, Inova Schar Cancer Institute, Inova Health System, Fairfax, Virginia.
Jiang ChangDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
James Chung Man HoDepartment of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yataro DaigoCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Shiga, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takayuki HondaDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Hideo KunitohDepartment of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
Shun-Ichi WatanabeDepartment of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Haruhiko NakayamaDepartment of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Shingo MatsumotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Masahiro TsuboiDepartment of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Koichi GotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Akiteru GotoDepartment of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan.
Yoshihiro MinamiyaDepartment of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita, Japan.
Kimihiro ShimizuDepartment of Surgery, Division of General Thoracic Surgery, Shinshu University School of Medicine Asahi, Nagano, Japan.
Kazumi TanakaDepartment of Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan.
Tangchun WuInstitute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Fusheng WeiChina National Environmental Monitoring Center, Beijing, People's Republic of China.
Jian SuGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Yeul Hong KimDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
In-Jae OhLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasuneup, Republic of Korea.
Victor Ho Fun LeeDepartment of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
Wu-Chou SuDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yuh-Min ChenDepartment of Chest Medicine, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Gee-Chen ChangSchool of Medicine and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan; Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Kuan-Yu ChenDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Ming-Shyan HuangDepartment of Internal Medicine, E-Da Cancer Hospital, I-Shou University and Kaohsiung Medical University, Kaohsiung, Taiwan.
Hsien-Chih LinInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Adeline SeowDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Jae Yong ParkLung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Sun-Seog KweonDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Jeonnam Regional Cancer Center, Chonnam National University, Hwasun, Republic of Korea.
Chien-Jen ChenGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, People's Republic of China.
Chen WuDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Biyun QianDepartment of Epidemiology and Biostatistics, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
Daru LuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Jianjun LiuLung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea; Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore; School of Life Sciences, Anhui Medical University, Hefei, People's Republic of China.
Hyo-Sung JeonCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Chin-Fu HsiaoInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jae Sook SungDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Ying-Huang TsaiDepartment of Respiratory Therapy, Chang Gung University, Taoyuan, Taiwan; Department of Pulmonary and Critical Care, Xiamen Chang Gung Hospital, Xiamen, People's Republic of China.
Yoo Jin JungDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Huan GuoDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Zhibin HuDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Tzu-Yu ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Laurie BurdettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Wei WuDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Junwen WangDivision of Applied Oral Sciences & Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China; State Key LaState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, Chinaboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, People's Republic of China.
Jin Eun ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Kyong Hwa ParkDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Sook Whan SungState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, People's Republic of China.
Li LiuDepartment of Oncology, Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Chang Hyun KangDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Chung-Hsing ChenNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Jun XuSchool of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, People's Republic of China.
Wen TanDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Chih-Liang WangDivision of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Alan Dart Loon SihoeCUHK Medical Centre, Hong Kong, China.
Ying ChenSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Yi Young ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Jun Suk KimDepartment of Internal Medicine, Division of Medical Oncology, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Ho-Il YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
In Kyu ParkDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ping XuDepartment of Oncology, Wuhan Iron and Steel (Group) Corporation Staff-Worker Hospital, Wuhan, People's Republic of China.
Qincheng HeState Key LaState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, Chinaboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, People's Republic of China.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Junjie WuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Wei-Yen LimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Kun-Chieh ChenDepartment of Internal Medicine, Division of Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
John K C ChanDepartment of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
Jihua LiQujing Center for Diseases Control and Prevention, Qujing, People's Republic of China.
Hongyan ChenMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Chong-Jen YuDepartment of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Li JinMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Jie LiuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Taiki YamajiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Yang YangShanghai Pulmonary Hospital, Shanghai, People's Republic of China.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland.
Kathleen WyattDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland.
Shengchao A LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland.
Hongxia MaCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Bao SongDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Zhehai WangDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Sensen ChengDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, People's Republic of China.
Yangwu RenDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, People's Republic of China.
Motoki IwasakiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Junjie ZhuEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, Maryland.
Gening JiangEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, Maryland.
Ke FeiEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, Maryland.
Guoping WuGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Li-Hsin ChienDepartment of Applied Mathematics, Chung Yuan Christian University, Chong-Li, Taiwan; Department of Applied Mathematics, National Dong Hwa University, Hualien, Taiwan.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
Jinming YuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Victoria L StevensLaboratory Services, American Cancer Society, Decatur, Georgia.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Dongxin LinSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Kexin ChenDepartment of Epidemiology and Biostatistics, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
Yi-Long WuGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
Keitaro MatsuoDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Kouya ShiraishiDivision of Genome Biology, National Cancer Research Institute, Tokyo, Japan.
Hongbing ShenDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Takashi KohnoDivision of Genome Biology, National Cancer Research Institute, Tokyo, Japan.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Funding
THE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MOvercoming acquired resistance to EGFR inhibitors in lung cancerR01CA121210 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LOVLY, CHRISTINE M. · 2007 to 2016
$2.9MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MRobust Methods for Polygenic Analysis to Inform Disease Etiology and Enhance Risk PredictionR01HG010480 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI CHATTERJEE, NILANJAN · 2019 to 2023
$2.8MINFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8MFOLLOW-UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY N01RC37004 · NCI · NATIONAL INSTITUTE FOR HEALTH & WELFARE · 2007 to 2008
$561kVLA-4 And VCAM-1 in Advanced AtherosclerosisR01HL079112 · NHLBI · UNIVERSITY OF WASHINGTON · PI HARLAN, JOHN MARSHALL · 2005 to 2005
$379kFOLLOW UP OF THE ALPHA TOCOPHEROL, BETA CAROTENE LUNGN01CN045035 · CN · NATIONAL PUBLIC HEALTH INSTITUTE · PI VIRTAMO, JARMO · 1994 to 1997
–U S-FINLAND STUDIES OF NUTRITION AND CANCERN01CN045165 · CN · NATIONAL PUBLIC HEALTH INSTITUTE · PI HEINONEN, O · 1985 to 1996
–CCR NIH HHS N01RC37004Intramural NIH HHS Z99 CA999999NCI NIH HHS N01 CN045035NCI NIH HHS N01 CN045165NCI NIH HHS N01 CN25404NCI NIH HHS N01 CN25476NCI NIH HHS N01 CN25511NCI NIH HHS N01 CN25512NCI NIH HHS N01 CN25513NCI NIH HHS N01 CN25514NCI NIH HHS N01 CN25515NCI NIH HHS N01 CN25516NCI NIH HHS N01 CN25518NCI NIH HHS N01 CN25522NCI NIH HHS N01 CN25524NCI NIH HHS N01 CN75022NCI NIH HHS N02CP11010NCI NIH HHS R01 CA121210NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA167462NCI NIH HHS U19 CA148127NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA182910NHGRI NIH HHS R01 HG010480NHLBI NIH HHS R01 HL079112
Abstract
We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67-13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44-5.00) (p-heterogeneity = 3.66 × 10
Indexed as
Adenocarcinoma of LungLung NeoplasmsMultifactorial InheritanceMutationAgedCase-Control StudiesErbB ReceptorsFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMiddle AgedNon-SmokersPrognosisRisk FactorsEGFR protein, humanErbB ReceptorsEGFR mutationLung adenocarcinomaNever-smokersPolygenic risk score
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.