Evidence map›Paper›PMID 39581292›Full record

ArticleBiological psychiatry2025

Multimodal Investigations of Structural and Functional Brain Alterations in Anorexia and Bulimia Nervosa and Their Relationships to Psychopathology.

Xinyang Yu, Lauren Robinson, Marina Bobou, Zuo Zhang, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan and 22 more

Abstract read
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In one paragraph

Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Bulimia nervosa.Nature reviews. Disease primers · 2026
    Review
  2. Clinical staging for eating disorders: A scoping review and update.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  3. Article
  4. Article
  5. MidbrainbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Xinyang YuSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Lauren RobinsonDepartment of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom; Oxford Institute of Clinical Psychology Training and Research, Oxford University, Oxford, United Kingdom.
Marina BobouSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom.
Zuo ZhangSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine, Dublin and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Antoine GrigisNeuroSpin, Commissariat à l'Energie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt, Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, Institut National de la Santé et de la Recherche Médical U1299 "Developmental trajectories & psychiatry", Université Paris-Saclay, Université Paris Cité, Centre National de la Recherche Scientifique, Centre Borelli UMR9010, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, Institut National de la Santé et de la Recherche Médical U1299 "Developmental trajectories & psychiatry", Université Paris-Saclay, Université Paris Cité, Centre National de la Recherche Scientifique, Centre Borelli UMR9010, Gif-sur-Yvette, France; AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, Institut National de la Santé et de la Recherche Médical U1299 "Developmental trajectories & psychiatry", Université Paris-Saclay, Université Paris Cité, Centre National de la Recherche Scientifique, Centre Borelli UMR9010, Gif-sur-Yvette, France; Psychiatry Department, EPS Barthélémy Durand, Étampes, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, Commissariat à l'Energie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France.
Hervé LemaîtreNeuroSpin, Commissariat à l'Energie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France; Institut des Maladies Neurodégénératives, UMR 5293, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, Université de Bordeaux, Bordeaux, France.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christian BäuchlFaculty of Psychology, Technische Universität Dresden, Dresden, Germany; Department of Psychiatry, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Argyris StringarisDivision of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt, Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Julia SinclairClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine, Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Berlin, Germany; Centre for Population Neuroscience and Precision Medicine, Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, China.
Ulrike SchmidtDepartment of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom.
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address: sylvane.desrivieres@kcl.ac.uk.
IMAGEN, STRATIFY, and ESTRA Consortia

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurobiological understanding of eating disorders (EDs) is limited. This study presents the first comparative multimodal magnetic resonance imaging assessments of anorexia nervosa and bulimia nervosa and uncovers neurobiological differences associated with these disorders.

methodsThis case-control study included 57 healthy female control participants and 130 female participants with EDs (bulimia nervosa and anorexia nervosa subtypes). Structural and functional magnetic resonance imaging assessed gray matter volume (GMV), cortical thickness, and task-based activities related to reward processing, socioemotional functioning, and response inhibition. Whole-brain group differences were correlated with ED psychopathology.

resultsSignificant structural differences were observed in the ED group compared with healthy control participants, including reduced GMV in the left lateral orbitofrontal cortex and lower cortical thickness in the left rostral middle frontal gyrus and precuneus after adjusting for body mass index. Specific structural alterations were only evident in anorexia nervosa subgroups. GMV reductions in the orbitofrontal cortex were linked to impulsivity, while lower cortical thickness in the frontal gyrus correlated with cognitive restraint in eating, suggesting that these regions may play key roles in ED psychopathology. Functional magnetic resonance imaging also revealed notable differences. During reward anticipation, participants with EDs exhibited deactivations in the cerebellum and right superior frontal gyrus together with reduced activation in the left lingual gyrus. These functional changes were associated with heightened neuroticism. Mediation analyses suggested that starvation-related GMV reductions in EDs disrupt reward-related brain function, increase neuroticism, and reinforce cognitive restraint, likely contributing to the persistence of ED symptoms.

conclusionsThese findings illuminate key neurobehavioral mechanisms that underlie EDs and point to potential brain-based targets for developing specialized treatment.

Indexed as

Anorexia NervosaBrainBulimia NervosaAdolescentAdultCase-Control StudiesFemaleGray MatterHumansMagnetic Resonance ImagingMultimodal ImagingRewardYoung AdultAnorexia nervosaBulimia nervosaCognitive restraintEating disorderMagnetic resonance imagingReward processing

Identifiers

PMID39581292
PMCPMC7619009

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