Evidence map›Paper›PMID 39580808›Full record

ArticleInternational journal of cancer2025

Global variations in gallbladder cancer incidence: What do recorded data and national estimates tell us?

Marion Piñeros, Jerome Vignat, Murielle Colombet, Mathieu Laversanne, Catterina Ferreccio, Katy Heise, Sharayu Mhatre, Jill Koshiol, Freddie Bray

Abstract read
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. The Chile BiLS case-control study of gallbladder cancer.Archives of public health = Archives belges de sante publique · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marion PiñerosCancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-4249-7276
Jerome VignatCancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
Murielle ColombetCancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
Mathieu LaversanneCancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
Catterina FerreccioSchool of Public Health, School of Medicine, Pontificia Universidad Católica de Chile (UC), Santiago de Chile, Chile.
Katy HeiseSubdirección Medica, Valdivia Hospital-Based Registry, Valdivia, Chile.
Sharayu MhatreDivision for Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Kharghar, Navi Mumbai, India.ORCID 0000-0001-7072-802X
Jill KoshiolInfections and Immunoepidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-3832-6204
Freddie BrayCancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-3248-7787

Funding

Etiology of Biliary Tract CancerZIACP010218 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KOSHIOL, JILL · 2011 to 2025
$30.4M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010218World Health Organization 001
6 · The paper itself

Abstract

On a global scale, gallbladder cancer is a relatively rare cancer with a striking variability in incidence across countries and world regions. We examined recent geographic variations worldwide based on national gallbladder cancer incidence estimates for the year 2022 from the GLOBOCAN database for 185 countries alongside recorded incidence data from the most recent volume of Cancer Incidence in Five Continents. In 2022, 122,491 new gallbladder cancer cases and 89,055 deaths were estimated to occur worldwide, of which 64.5% and 64.7% respectively were among females. The highest reported rates (ASR per 100,000) were in subpopulations of Northeastern regions of India and Southern Chile in both males (ASR of 6.1 and 5.3, respectively) and in females, though rates were two times higher than males (ASR of 14.9 and 15.4). The lowest incidence rates were reported in subpopulations of Uganda for males and South Africa for females (0.21 and 0.14, respectively). Recorded gallbladder cancer incidence rates among subnational populations within countries differed considerably from their respective national estimates and revealed a 100-fold variation in gallbladder cancer, highlighting the importance of subnational population-based cancer registry data in pinpointing areas of high risk, driving research and prioritizing tailored public health actions.

Indexed as

Gallbladder NeoplasmsFemaleGlobal HealthHumansIncidenceMaleRegistriesburdengallbladderincidenceneoplasmsregistries

Identifiers

PMID39580808
PMCPMC12351455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.