Evidence map›Paper›PMID 39580681›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2024

Magnetically Responsive Enzyme and Hydrogen-Bonded Organic Framework Biocomposites for Biosensing.

Francesco Carraro, Margherita Aghito, Simone Dal Zilio, Heimo Wolinski, Christian J Doonan, Bernd Nidetzky, Paolo Falcaro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Design, Synthesis, and Application of Immobilized Enzymes on Artificial Porous Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco CarraroInstitute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria.ORCID 0000-0001-8485-4676
Margherita AghitoInstitute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria.ORCID 0009-0001-4651-6884
Simone Dal ZilioInstituto Officina dei Materiali, CNR, Basovizza, Edificio MM-SS, Trieste, 34149, Italy.ORCID 0000-0003-0337-7068
Heimo WolinskiInstitute of Molecular Biosciences, Field of Excellence BioHealth, University of Graz, Graz, 8010, Austria.ORCID 0000-0002-1583-6092
Christian J DoonanDepartment of Chemistry and Centre for Advanced Nanosmaterials, University of Adelaide, Adelaide, South Australia, 5005, Australia.ORCID 0000-0003-2822-0956
Bernd NidetzkyInstitute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12/1, Graz, 8010, Austria.ORCID 0000-0002-5030-2643
Paolo FalcaroInstitute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria.ORCID 0000-0001-5935-0409

Funding

TU Graz
6 · The paper itself

Abstract

The one-pot synthesis of multicomponent hydrogen-bonded organic framework (HOF) biocomposites is reported. The co-immoblization of enzymes and magnetic nanoparticles (MNPs) into the HOF crystals yielded biocatalysts (MNPs-enzyme@BioHOF-1) with dynamic localization properties. Using a permanent magnet, it is possible to separate the MNPs-enzyme@BioHOF-1 particles from a solution. Catalase (CAT) and glucose oxidase (GOx) show increased retention of their activity when coimmobilized with MNPs. MNPs-GOx@BioHOF-1 biocomposites are used to prepare a proof-of-concept glucose microfluidic biosensor, where a magnet allow to position and keep in place the biocomposite inside a microfluidic chip. The magnetic response of these biocatalysts can pave the way for new applications for the emerging HOF biocomposites.

Indexed as

Biosensing TechniquesGlucose OxidaseHydrogen BondingCatalaseEnzymesEnzymes, ImmobilizedGlucoseMagnetite NanoparticlesCatalaseEnzymesEnzymes, ImmobilizedGlucoseGlucose OxidaseMagnetite NanoparticlesbiocatalysisbiocompositebiosensorenzymeHOF

Identifiers

PMID39580681
PMCPMC11673408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.