Evidence map›Paper›PMID 39580666›Full record

ArticleAdvanced healthcare materials2025

Granular Nanofiber-Hydrogel Composite-Programmed Regenerative Inflammation and Adipose Tissue Formation.

Jiayuan Kong, Zhi-Cheng Yao, Jessica L Stelzel, Yueh-Hsun Yang, Jeffrey Chen, Hexiang Feng, Collin Schmidt, Chi Zhang, Kedar Krishnan, Long Chen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiayuan KongDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-5368-8940
Zhi-Cheng YaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-3086-6038
Jessica L StelzelTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.ORCID 0000-0002-5644-9240
Yueh-Hsun YangTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.ORCID 0000-0003-0298-8641
Jeffrey ChenTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Hexiang FengTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Collin SchmidtDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Chi ZhangDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0001-8201-3953
Kedar KrishnanTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Long ChenDepartment of Orthopaedics, Guizhou Provincial People's Hospital, Guiyang, Guizhou, 550000, P. R. China.ORCID 0000-0002-7347-3074
Jingwen PanDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Kailei DingDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Yining ZhuTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Xiaowei LiDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Joshua C DoloffDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-4323-3264
Hai-Quan MaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-4262-9988
Sashank K ReddyTranslational Tissue Engineering Centre, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.ORCID 0000-0001-6323-3950

Funding

Biostimulatory nanofiber-hydrogel composite for soft tissue remodelingR01DE031488 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI AARON W JAMES, Hai-Quan Mao · 2022 to 2026
$2.8M
A nanofiber-hydrogel composite plug for perianal fistula repairR01DK135269 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Hai-Quan Mao, Florin Selaru · 2023 to 2026
$2.6M
LifeSprout Inc.Maryland Stem Cell Research Fund MSCRFL5375NIDCR NIH HHS R01 DE031488NIDCR NIH HHS R01DE031488NIDDK NIH HHS R01 DK135269NIDDK NIH HHS R01DK135269
6 · The paper itself

Abstract

The interplay between biomaterials and host immune responses critically determines outcomes in tissue restoration. Recent studies suggest that physicochemical properties of materials can dictate pro-regenerative versus pro-fibrotic responses and have begun to define the key immune cell types and signals governing these divergent effects. This emerging understanding enables the engineering of regenerative biomaterials capable of functional restoration in situ. An injectable nanofiber-hydrogel composite (NHC) microparticles are designed and constructed from cross-linked electrospun collagen nanofiber fragments surface-bonded to the hyaluronic acid hydrogel network via covalent conjugation during the cross-linking process. The collagen nanofiber fragments, acting as the structural reinforcement component, increased the overall storage modulus of the NHC to a level comparable to native soft tissues while maintaining a sufficiently high degree of porosity of the hydrogel phase to allow host cell infiltration following subcutaneous injection of the NHC microparticles. More importantly, the NHC promoted macrophage/monocyte infiltration, migration, and spreading, sustained cell recruitment over time, and enhanced the proangiogenic effect and recruitment of PDGFRα

Indexed as

Adipose TissueHydrogelsInflammationNanofibersRegenerationAnimalsBiocompatible MaterialsCollagenMacrophagesMiceTissue EngineeringBiocompatible MaterialsCollagenHydrogelsbiomaterialshydrogelsregenerative inflammationssoft tissue restoration

Identifiers

PMID39580666
PMCPMC11773126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.