ArticleBiophysical journal2025
Structural dynamics of contractile injection systems.
Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Physics of a super-fast viral jab.Biophysical journal · 2025Article
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2 authors.
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Abstract
The dynamics of many macromolecular machines are characterized by chemically mediated structural changes that achieve large-scale functional deployment through local rearrangements of constitutive protein subunits. Motivated by recent high-resolution structural microscopy of a particular class of such machines, contractile injection systems (CISs), we construct a coarse-grained semianalytical model that recapitulates the geometry and bistability of CISs in terms of a minimal set of measurable physical parameters. We use this model to predict the size, shape, and speed of a dynamical actuation front that underlies contraction. Scaling laws for the velocity and physical extension of the contraction front are consistent with our numerical simulations and may be generally applicable to related systems.
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