Evidence map›Paper›PMID 39580609›Full record

ArticleNPJ digital medicine2024

Spatial resolution enhancement using deep learning improves chest disease diagnosis based on thick slice CT.

Pengxin Yu, Haoyue Zhang, Dawei Wang, Rongguo Zhang, Mei Deng, Haoyu Yang, Lijun Wu, Xiaoxu Liu, Andrea S Oh, Fereidoun G Abtin and 14 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  19. An interpretableFrontiers in oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Pengxin Yu *College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning, China.ORCID http://orcid.org/0000-0003-4065-0377
Haoyue Zhang *National cancer institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9412-7584
Dawei WangInfervision Medical Technology Co., Ltd, Beijing, China.
Rongguo ZhangAcademy for Multidisciplinary Studies, Beijing National Center for Applied Mathematics, Capital Normal University, Beijing, China.
Mei DengChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Haoyu YangPeking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Lijun WuDepartment of Radiology, Chinese PLA General Hospital First Medical Center, Beijing, China.
Xiaoxu LiuDepartment of Radiology, Beijing Haidian Section of Peking University Third Hospital, Beijing, China.
Andrea S OhDepartment of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Fereidoun G AbtinDepartment of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Ashley E ProsperDepartment of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Kathleen RuchalskiDepartment of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Nana WangDepartment of Radiology, Beijing Haidian Section of Peking University Third Hospital, Beijing, China.
Huairong ZhangDepartment of Radiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Ye LiDepartment of Radiology, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Xinna LvDepartment of Radiology, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Min LiuDepartment of Radiology, China-Japan Friendship Hospital, Beijing, China.
Shaohong ZhaoDepartment of Radiology, Chinese PLA General Hospital First Medical Center, Beijing, China.
Dasheng LiDepartment of Radiology, Beijing Haidian Section of Peking University Third Hospital, Beijing, China.
John M HoffmanDepartment of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Denise R AberleDepartment of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Chaoyang LiangDepartment of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China.
Shouliang QiCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning, China. qisl@bmie.neu.edu.cn.
Corey ArnoldDepartment of Radiological Sciences, Pathology & Laboratory Medicine, Electrical & Computer Engineering, and Bioengineering, University of California Los Angeles, Los Angeles, CA, USA. cwarnold@mednet.ucla.edu.

Funding

National Science Foundation of China | Major Research Plan 2021ZD01111104
6 · The paper itself

Abstract

CT is crucial for diagnosing chest diseases, with image quality affected by spatial resolution. Thick-slice CT remains prevalent in practice due to cost considerations, yet its coarse spatial resolution may hinder accurate diagnoses. Our multicenter study develops a deep learning synthetic model with Convolutional-Transformer hybrid encoder-decoder architecture for generating thin-slice CT from thick-slice CT on a single center (1576 participants) and access the synthetic CT on three cross-regional centers (1228 participants). The qualitative image quality of synthetic and real thin-slice CT is comparable (p = 0.16). Four radiologists' accuracy in diagnosing community-acquired pneumonia using synthetic thin-slice CT surpasses thick-slice CT (p < 0.05), and matches real thin-slice CT (p > 0.99). For lung nodule detection, sensitivity with thin-slice CT outperforms thick-slice CT (p < 0.001) and comparable to real thin-slice CT (p > 0.05). These findings indicate the potential of our model to generate high-quality synthetic thin-slice CT as a practical alternative when real thin-slice CT is preferred but unavailable.

Identifiers

PMID39580609
PMCPMC11585608

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.