Evidence map›Paper›PMID 39580604›Full record

ArticleMolecular psychiatry2025

Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction.

Yoshikazu Morishita, Ileana Fuentes, Sofia Gonzalez-Salinas, John Favate, Jennifer Mejaes, Ko Zushida, Akinori Nishi, Charles Hevi, Noriko Goldsmith, Steve Buyske and 8 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yoshikazu Morishita *Department of Genetics, Rutgers University, Piscataway, NJ, USA.
Ileana Fuentes *Department of Genetics, Rutgers University, Piscataway, NJ, USA.
Sofia Gonzalez-Salinas *Department of Genetics, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-2374-8228
John FavateDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Jennifer MejaesDepartment of Psychology, Rutgers University, Piscataway, NJ, USA.
Ko ZushidaDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Akinori NishiDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Charles HeviDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Noriko GoldsmithKeck Center, Rutgers University, Piscataway, NJ, USA.
Steve BuyskeDepartment of Statistics, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0001-8539-5416
Stephanie E SillivanDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Courtney A MillerDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
Eric R KandelHoward Hughes Medical Institute, Columbia University, New York, NY, USA.
Shusaku UchidaDepartment of Integrative Anatomy, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Premal ShahDepartment of Genetics, Rutgers University, Piscataway, NJ, USA. premal.shah@rutgers.edu.ORCID 0000-0002-8424-4218
Juan Marcos AlarconDepartment of Pathology, Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. JuanMarcos.Alarcon@downstate.edu.ORCID 0000-0002-3936-806X
David J BarkerDepartment of Psychology, Rutgers University, Piscataway, NJ, USA. david.barker@rutgers.edu.ORCID 0000-0002-4609-6787
Gleb P ShumyatskyDepartment of Genetics, Rutgers University, Piscataway, NJ, USA. gleb@hginj.rutgers.edu.ORCID 0000-0002-2036-4114

Funding

Activity-Dependent Cellular and Molecular Events Regulating MemoryR01MH107555 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI SHUMYATSKY, GLEB P · 2016 to 2020
$1.9M
Dynamics and evolution of translational regulationR35GM124976 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SHAH, PREMAL R · 2017 to 2021
$1.9M
The Role of Corticolimbic Circuits in Maternal BehaviorR01HD113761 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI GLEB P SHUMYATSKY, Premal R Shah · 2024 to 2026
$1.6M
The role of GRP and GRPergic circuitry in fear memoryR01MH080328 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI SHUMYATSKY, GLEB P · 2009 to 2010
$1.2M
Defining the differential roles of Glutamatergic and GABAergic projections from the Lateral Preoptic Area to the Lateral Habenula in Reward, Aversion, and Drug-Seeking Behavior.R00DA043572 · NIDA · RUTGERS, THE STATE UNIV OF N.J. · PI BARKER, DAVID J · 2019 to 2021
$747k
The role of microtubule network in a mouse model of Alzheimer’s diseaseR03AG085121 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI ALARCON, JUAN MARCOS, SHUMYATSKY, GLEB P · 2024 to 2025
$305k
NIA NIH HHS R03 AG085121NICHD NIH HHS R01 HD113761NIDA NIH HHS K99 DA043572NIDA NIH HHS R00 DA043572NIGMS NIH HHS R35 GM124976NIMH NIH HHS R01 MH080328NIMH NIH HHS R01 MH107555
6 · The paper itself

Abstract

Fear extinction leads to a decrease of originally acquired fear responses after the threat is no longer present. Fear extinction is adaptive and critical for organism's survival, but deficits in extinction may lead to exaggerated fear in animals or post-traumatic stress disorder (PTSD) in humans. Dopamine has recently emerged as essential for fear extinction and PTSD, however the neural circuits serving this dopamine function are only beginning to be investigated, and the dopamine intracellular signaling pathways are unknown. We generated gastrin-releasing peptide gene knockout (Grp

Indexed as

DopamineGastrin-Releasing PeptideAmygdalaAnimalsBasolateral Nuclear ComplexConditioning, ClassicalExtinction, PsychologicalFearGene ExpressionLearningMaleMiceMice, Inbred C57BLMice, KnockoutStress Disorders, Post-TraumaticStress, PsychologicalDopamineGastrin-Releasing Peptide

Identifiers

PMID39580604
PMCPMC12092189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.