Evidence map›Paper›PMID 39580556›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Relationship of anatomical variations of sphenoid sinus and the outcomes of endoscopic endonasal transsphenoidal surgeries: a systematic review.

Dur-E-Shewar Rehman, Zul Izhar Mohd Ismail, Dunia Jawdat, Syed Adnan Ali, Nur Asma Sapiai, Akeel AlAli

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dur-E-Shewar RehmanDepartment of Anatomy, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, 16150, Malaysia.ORCID http://orcid.org/0000-0002-3898-0943
Zul Izhar Mohd IsmailDepartment of Anatomy, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, 16150, Malaysia. zulizhar@usm.my.ORCID http://orcid.org/0000-0002-3732-8240
Dunia JawdatBasic Sciences Department, College of Sciences and Health Professions, King Saud bin, Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard, Prince Mutib Ibn Abdullah Ibn Abdulaziz Rd, Ar Rimayah, Riyadh, 11481, Saudi Arabia.ORCID http://orcid.org/0000-0002-3615-2909
Syed Adnan AliGovernment Degree Science and Commerce College, Korangi 6, Karachi, Pakistan.ORCID http://orcid.org/0000-0001-5790-149X
Nur Asma SapiaiDepartment of Radiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, 16150, Malaysia.ORCID http://orcid.org/0000-0002-7955-9768
Akeel AlAliKing Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard, Ahmad Ibn Hanbal Street, Ar Rimayah, Riyadh, 11481, Saudi Arabia.ORCID http://orcid.org/0000-0003-4619-7489

Funding

Universiti Sains Malaysia Graduate Student Financial Assistance (GRA-Assist) [Grant number GRA23-0217]
6 · The paper itself

Abstract

backgroundThe sphenoid sinus features many anatomical variations between individuals from different populations in the world. The understanding of these variations is important for the surgeons to plan for surgeries which involve intervention through the nasal approach. The aim of the present systematic review was to perform a qualitative synthesis of available studies which assess the effect of sphenoid sinus (SS) anatomical variations on the outcomes of endoscopic endonasal transsphenoidal surgeries (ETSS).

methodsThe current review followed PRISMA 2020 guidelines. A systematic advanced electronic search was performed in four databases Medline (via PubMed), Scopus, Web of Science (WoS) and Lilacs in December 2023. Studies that assessed the anatomical variations of the SS that affect the outcomes of ETSS were eligible for inclusion. A qualitative synthesis of the methodology and results of the included studies was carried out. Quality assessment was performed using the National Institute of Health (NIH) quality assessment tool (last accessed on December 24, 2023).

resultsA total of 14 studies were included in the qualitative synthesis. Most of the studies included in the review found that the sellar pneumatization was the commonest followed by the postsellar type. Single intersphenoid sinus septum (ISS) was found to be the most common variation, which is more frequently found in males compared to females. There was sex difference seen in the attachment of the ISS to the carotid canal. It is more commonly attached to the posterolateral wall of the sinus in males compared to the females. Though complicated cases were less compared to uncomplicated ones, cerebrospinal fluid (CSF) leak was the leading post operative complication amongst the complicated cases and paranasal sinus (PNS) computed tomography (CT) scan showed ISS findings differed from intraoperative findings.

conclusionIt is concluded that the ISS poses the commonest anatomical variations encountered during the ETSS. During planning for transsphenoidal endoscopic procedure, the ISS should thoroughly be assessed to minimize potential surgical complications.

Indexed as

Anatomic VariationEndoscopyNatural Orifice Endoscopic SurgerySphenoid SinusHumansTreatment OutcomeCerebrospinal fluid leakEndoscopic surgeryIntersphenoid sinus septumPneumatizationSphenoid sinus

Identifiers

PMID39580556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.