ArticleBMC pregnancy and childbirth2024
Effect of day 3 embryo cell number on the pregnancy and neonatal outcomes of day 4 single embryo transfer from fresh cycles.
Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Late-stage vacuolization as a compaction-dependent prognostic marker for day 4 embryo selection.Reproduction & fertility · 2026Article
- Clinical outcomes of co-transfer of partially and fully compacted morula versus fully compacted morula alone on day 4.Frontiers in endocrinology · 2026Article
- Development and validation of a predictive model for early blastocyst formation on day 4 post-fertilization.Frontiers in endocrinology · 2026Article
- Effect of day 3 cell number on the pregnancy and neonatal outcomes of vitrified-warmed single blastocyst transfer.European journal of medical research · 2025Article
- Interaction between embryo transfer timing (D3/D4) and duration of progesterone exposure (P3/P4) on live birth rate in hormone replacement therapy cycles of frozen embryo transfer.Reproductive biology and endocrinology : RB&E · 2025Article
- Association between pretransfer cleavage-stage blastomere dynamics and pregnancy outcomes in fresh single embryo transfer cycles: a retrospective cohort study.Frontiers in endocrinology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe aim of this retrospective cohort study was to assess the impact of day 3(D3) embryo cell number on the clinical pregnancy and neonatal outcomes of day 4(D4) single embryo transfer in fresh cycles.
methodsThe study included 431 day 4 single embryo transfer in fresh cycles conducted between December 2018 and June 2023. These cycles were divided into three groups according to the day 3 embryo cell number: 248 cycles in the 7 ~ 9-cell group, 149 cycles in the 10 ~ 13-cell group and 34 cycles in the >13-cell group, and clinical pregnancy outcomes and neonatal outcomes were compared among the three groups.
resultsThe clinical outcomes with 10 ~ 13-cell were significantly higher than those of the 7 ~ 9-cell group, regardless of whether the female age was < 30 or ≥ 30 years. The same result could be found when the insemination pattern was IVF, and when the transferred embryos were the grade of complete fusion. There were no differences in neonatal outcomes between different groups.After adjusting for confounding factors, the 7 ~ 9-cell group was associated with lower clinical pregnancy rates(CBR) and live birth rates(LBR) compared with the 10 ~ 13-cell group (CPR: aOR 0.527, 95% CI 0.317 ~ 0.874, P = 0.013; LBR: aOR 0.499, 95% CI 0.308 ~ 0.807, P = 0.005).
conclusionThe cell number of D3 embryos can be an important reference indicator for D4 embryo selection. When performing day 4 single embryo transfer in fresh cycles, embryos with 10 ~ 13-cell on D3 can be preferentially selected for transplantation to enhance clinical outcomes, especially when the insemination pattern is IVF, and when the transferred embryos are the grade of compaction stage.
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