ArticleChest2025
Plasma Protein Biomarkers of Spirometry Measures of Impaired Lung Function.
Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease.ERJ open research · 2026Article
- Circulating proteomic landscape of lung function.The European respiratory journal · 2026Article
- Proteomic Profiling of Pulmonary Function and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2026Observational
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundImpaired pulmonary function carries significant risks for lung, cardiovascular, and metabolic disorders. RESEARCH QUESTION: Can circulating protein biomarkers of pulmonary function provide insight into the pathophysiologic features of lung function impairment and links to comorbidities? STUDY DESIGN AND
methodsWe analyzed plasma levels of 2,922 proteins in 32,493 UK Biobank participants (53% female; mean [SD] age, 57 [8] years) to investigate their associations with spirometry measures of lung function (FEV
resultsIn the UK Biobank, we identified 1,240 proteins associated significantly (P < .000017 observed in the UK Biobank) with FEV
interpretationThis study identified proteomic signatures of reduced lung function linked to comorbidities, paving the way for improved diagnostics for and treatment of lung disease.
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Registered trials
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