ArticleJournal of the mechanical behavior of biomedical materials2025
Prediction of vertebral failure under general loadings of compression, flexion, extension, and side-bending.
Article in Journal of the mechanical behavior of biomedical materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Viscoelastic Modeling for Failure Analysis of Human Vertebral Bone Undergoing Quasi-Static and Dynamic Compression.Bioengineering (Basel, Switzerland) · 2026Article
- Optimization of Bone Cement Stiffness in Metastatic Vertebral Augmentation: Balancing Strength Restoration and Stress Redistribution.Annals of biomedical engineering · 2026Article
- Segmental asymmetry and multiplanar motion of the lumbar spine: Cadaveric insights into spinal pathologies.Journal of the mechanical behavior of biomedical materials · 2026Article
- Biomechanical effects of defect size and location on vertebral fracture.Journal of medical and biological engineering · 2025Article
- Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size.International journal for numerical methods in biomedical engineering · 2025Article
- Effects of Age and Muscle Activation on Three-Dimensional Spine Kinematics and Asymmetry in Elderly Adults.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Bone pathologies such as osteoporosis and metastasis can significantly compromise the load-bearing capacity of the spinal column, increasing the risk of vertebral fractures, some of which may occur during routine physical activities. Currently, there is no clinical tool that accurately assesses the risk of vertebral fractures associated with these activities in osteoporotic and metastatic spines. In this paper, we develop and validate a quantitative computed tomography-based finite element analysis (QCT/FEA) method to predict vertebral fractures under general load conditions that simulate flexion, extension, and side-bending movements, reflecting the body's activities under various scenarios. Initially, QCT/FEA models of cadaveric spine cohorts were developed. The accuracy and verification of the methodology involved comparing the fracture force outcomes to those experimentally observed and measured under pure compression loading scenarios. The findings revealed a strong correlation between experimentally measured failure loads and those estimated computationally (R
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Registered trials
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