Evidence map›Paper›PMID 39579325›Full record

ReviewCurrent topics in behavioral neurosciences2025

Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.

Antonio Florido, Vincent R Curtis, Nicolas C Pégard, Jose Rodriguez-Romaguera

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in behavioral neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Antonio FloridoDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Vincent R CurtisDepartment of Applied Physical Sciences, University of North Carolina, Chapel Hill, NC, USA.
Nicolas C PégardDepartment of Applied Physical Sciences, University of North Carolina, Chapel Hill, NC, USA. pegard@unc.edu.
Jose Rodriguez-RomagueraDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. jose_rodriguezromaguera@med.unc.edu.

Funding

Encoding social arousal within prepronociceptin circuits in the extended amygdalaR01MH132073 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jose Rodriguez-Romaguera · 2023 to 2026
$2.7M
NIMH NIH HHS R01 MH132073
6 · The paper itself

Abstract

Anxiety disorders are prevalent and debilitating conditions characterized by excessive concern and fear, affecting thoughts, behaviors, and sensations. A critical component of anxiety is arousal, a complex process involving alertness regulation and stimulus salience modulation. While arousal is adaptive in normal circumstances, dysregulation can lead to hypoarousal or hyperarousal, affecting response selection and threat perception. This chapter reviews challenges in studying arousal in preclinical anxiety models, emphasizing the need for multicomponent measurement and analysis. Novel methodologies integrating physiological measurement with activity tracking of neurons with single-cell resolution in awake animals are discussed, with emphasis in current challenges. Understanding these mechanisms is crucial for developing effective treatments for anxiety disorders.

Indexed as

AnxietyAnxiety DisordersArousalBrainAnimalsDisease Models, AnimalHumansNeuronsAnxietyArousalBehaviorInternal physiologyStress

Identifiers

PMID39579325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.