Evidence map›Paper›PMID 39579151›Full record

ArticleAlcohol, clinical & experimental research2024

Alcohol use and cannabis craving in daily life: Sex differences and associations among young adults.

Christal N Davis, Nolan E Ramer, Lindsay M Squeglia, Kathryn S Gex, Aimee L McRae-Clark, Sherry A McKee, Walter Roberts, Kevin M Gray, Nathaniel L Baker, Rachel L Tomko

Abstract read
In one paragraph

Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christal N DavisDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0003-3974-5598
Nolan E RamerDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Lindsay M SquegliaDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0001-5994-6894
Kathryn S GexDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0001-7458-6508
Aimee L McRae-ClarkDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Sherry A McKeeDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Walter RobertsDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-6817-884X
Kevin M GrayDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Nathaniel L BakerDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Rachel L TomkoDepartment of Psychiatry and Behavioral Services, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Impact of Stress and Craving on Return to Postpartum Cannabis UseU54DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CONSTANCE GUILLE · 2018 to 2026
$15.9M
DRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8M
Clinical Scientists Training Program in Addictions at MUSCK12DA031794 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Kevin M. Gray, AIMEE L MCRAE-CLARK · 2013 to 2026
$7.2M
Interdisciplinary Women's Health Research at MUSCK12HD055885 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCGINTY, JACQUELINE F. · 2007 to 2021
$7.2M
MID-CAREER AWARD IN PATIENT-ORIENTED DRUG ABUSE RESEARCHK24DA038240 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCRAE-CLARK, AIMEE L · 2014 to 2023
$1.9M
Mentoring Clinical Investigators in Patient-Oriented Adolescent Alcohol ResearchK24AA031052 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Lindsay Squeglia · 2024 to 2026
$644k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K24 AA031052NICHD NIH HHS K12 HD055885NIDA NIH HHS K12 DA031794NIDA NIH HHS K24 DA038240NIDA NIH HHS T32 DA007288NIDA NIH HHS U54 DA016511NIH HHS K12DA031794NIH HHS K12 HD055885NIH HHS K24AA031052NIH HHS K24DA038240NIH HHS T32 DA007288NIH HHS U54DA016511
6 · The paper itself

Abstract

backgroundAlcohol and cannabis are commonly used together by young adults. With frequent pairings, use of one substance may become a conditioned cue for use of a second, commonly co-used substance. Although this has been examined for alcohol and cannabis in laboratory conditions and with remote monitoring, no research has examined whether pharmacologically induced cross-substance craving occurs in naturalistic conditions.

methodsIn a sample of 63 frequent cannabis-using young adults (54% female) who completed 2 weeks of ecological momentary assessment, we tested whether alcohol use was associated with stronger in-the-moment cannabis craving. We also examined whether sex moderated this association and whether cannabis craving was stronger at higher levels of alcohol consumption.

resultsAlthough alcohol use and cannabis craving were not significantly associated at the momentary level, there was evidence that this relation significantly differed by sex. Among female participants, there was a negative association between alcohol use since the last prompt and momentary cannabis craving (b = -0.33, SE = 0.14, p = 0.02), while the association among male participants was positive (b = 0.32, SE = 0.13, p = 0.01). Similarly, alcohol quantity was negatively associated with cannabis craving at the momentary level for female participants (b = -0.10, SE = 0.04, p = 0.009) but was not significantly associated for male participants (b = 0.05, SE = 0.04, p = 0.18).

conclusionsAlcohol may enhance cannabis craving among male individuals but reduce desire for cannabis among female individuals. This may point to differing functions of co-use by sex, highlighting a need for research to elucidate the mechanisms underlying this increasingly common pattern of substance use.

Indexed as

alcoholcannabiscravingecological momentary assessmentsex differences

Identifiers

PMID39579151
PMCPMC11629456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.