Evidence map›Paper›PMID 39578996›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Associations of Muscle-Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study.

Yongbing Lan, Yalei Ke, Dianjianyi Sun, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Silu Lv, Maxim Barnard, Junshi Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yongbing LanDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yalei KeDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Dianjianyi SunDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Pei PeiPeking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.
Ling YangClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Yiping ChenClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Huaidong DuClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Silu LvLicang Center for Disease Control and Prevention, Qingdao, China.
Maxim BarnardClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Junshi ChenChina National Center for Food Safety Risk Assessment, Beijing, China.
Zhengming ChenClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Jun LvDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Canqing YuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-0019-0014
China Kadoorie Biobank Collaborative Group

Funding

British Heart Foundation CH/1996001/9454Cancer Research UK C16077/A29186Cancer Research UK C500/A16896Chinese Ministry of Science and Technology 2011BAI09B01National Key R&D Program of China 2016YFC0900500National Major Science & Technology Projects 2023ZD0510100National Natural Science Foundation of China 81390540National Natural Science Foundation of China 81941018National Natural Science Foundation of China 82192900National Natural Science Foundation of China 82388102National Natural Science Foundation of China 91846303Oxford University 088158/Z/09/ZOxford University 104085/Z/14/ZOxford University 202922/Z/16/ZOxford University 212946/Z/18/ZUK Medical Research Council MC_U137686851UK Medical Research Council MC_UU_00017/1UK Medical Research Council MC_UU_12026/2
6 · The paper itself

Abstract

backgroundThere is limited evidence about the association of muscle mass, strength and quality with respiratory disease, especially in Chinese populations. We aimed to comprehensively examine such associations and identify better metrics with more clinical and public health relevance.

methodsWe conducted a prospective cohort study based on data from the second resurvey of the China Kadoorie Biobank (CKB) study in participants with no prevalent respiratory disease or cancer. Arm muscle quality was calculated as the ratio of grip strength to arm muscle mass. Low muscle mass, grip strength and arm muscle quality were defined as the sex-specific lowest quintiles of corresponding variables. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for respiratory disease.

resultsIn total, 17 510 participants aged 38-88 (65.4% women; mean age 57.8 ± 9.6) were enrolled in 2013-2014 and followed up until 31 December 2018. During a median follow-up of 4.82 years, 1346 participants developed respiratory disease. After adjustment for sociodemographic characteristics, lifestyle factors and medical histories, the elevated HR of respiratory disease was 1.31 (1.14-1.51) for low grip strength and 1.25 (1.09-1.44) for low arm muscle quality. Grip strength and arm muscle quality exhibited a linearly inverse association between respiratory disease (p = 0.137 and 0.102), with each standard deviation (SD) decrease in grip strength and arm muscle quality associated with a 22% (95% CI: 11%-34%) and 14% (95% CI: 7%-22%) increased risk of respiratory disease. No association was found for low total muscle mass index and low appendicular muscle mass index.

conclusionLow grip strength and arm muscle quality are associated with increased risks of respiratory disease, and they are better muscle-related metrics for identifying adults at high risk of respiratory disease. Chinese adults may need to maintain normal muscle mass, strength and quality to achieve better respiratory health, but this needs to be validated in appropriately designed clinical trials.

Indexed as

Hand StrengthAdultAgedAged, 80 and overChinaEast Asian PeopleFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthProspective StudiesRespiratory Tract Diseasesgrip strengthmuscle massmuscle qualityprospectiverespiratory disease

Identifiers

PMID39578996
PMCPMC11695270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.