Evidence map›Paper›PMID 39578992›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies.

Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada and 2 more

Abstract read
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Titi YangDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0009-0004-8071-355X
Emi OkadaGraduate School of Health Sciences, Okayama University, Okayama, Japan.
Maho TodorokiGraduate School of Health Sciences, Okayama University, Okayama, Japan.
Siyu LiuGraduate School of Health Sciences, Okayama University, Okayama, Japan.
Rukmali AthurupanaGraduate School of Health Sciences, Okayama University, Okayama, Japan.
Kumie KataokaGraduate School of Health Sciences, Okayama University, Okayama, Japan.
Chiaki KashinoReproduction Center, Okayama University Hospital, Okayama, Japan.
Takashi MitsuiReproduction Center, Okayama University Hospital, Okayama, Japan.
Toru HasegawaReproduction Center, Okayama University Hospital, Okayama, Japan.
Yasuhiko KamadaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Hisashi MasuyamaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Mikiya NakatsukaGraduate School of Health Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0002-0359-4516

Funding

Agenția Națională pentru Cercetare și Dezvoltare 21gk0110047h0003
6 · The paper itself

Abstract

objectiveAntiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.

methodsIn this retrospective study, 569 women with RPL and 55 healthy women who had never experienced pregnancy loss were recruited. We performed blood tests for aPL and acceleration plethysmography (APG) to evaluate peripheral vascular function.

resultsThe differential pulse wave index (DPI), indicating vascular elasticity, was significantly lower in women with RPL (115.6 ± 4.1) compared to the control group (117.0 ± 2.3). DPI in RPL women with anti-β

conclusionWomen with RPL have subclinical vascular dysfunction even at reproductive age. It is possible that aβ

Indexed as

Abortion, HabitualAntibodies, AntiphospholipidVascular DiseasesAdultbeta 2-Glycoprotein IBody Mass IndexCase-Control StudiesFemaleHumansImmunoglobulin GPlethysmographyPregnancyPulse Wave AnalysisRetrospective StudiesYoung AdultAntibodies, Antiphospholipidbeta 2-Glycoprotein IImmunoglobulin Gaccelerated photoplethysmographyantiphospholipid antibodiesanti‐β2 glycoprotein I antibodyrecurrent pregnancy lossvascular dysfunction

Identifiers

PMID39578992
PMCPMC11911946

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.