Evidence map›Paper›PMID 39578887›Full record

ArticleBiological research2024

Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats.

Camila Salazar-Ardiles, Carlos Cornejo, Cristobal Paz, Manuel Vasquez-Muñoz, Alexis Arce-Alvarez, Maria Rodriguez-Fernandez, Gregoire P Millet, Mikel Izquierdo, David C Andrade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Camila Salazar-ArdilesExercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile.
Carlos CornejoExercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile.
Cristobal PazExercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile.
Manuel Vasquez-MuñozDirección de Docencia de Especialidades Médicas, Dirección de Postgrado, Facultad de Medicina y Ciencias de la Salud, Universidad Mayor, Santiago, Chile.
Alexis Arce-AlvarezEscuela de Kinesiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastian, Santiago, Chile.
Maria Rodriguez-FernandezInstitute for Biological and Medical Engineering, Schools of Engineering, Medicine, and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Gregoire P MilletInstitute of Sport Sciences, University of Lausanne, Lausanne, CH-1015, Switzerland.
Mikel IzquierdoNavarrabiomed, Hospital Universitario de Navarra (UHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Navarra, Spain.
David C AndradeExercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile. david.andrade@uantof.cl.ORCID http://orcid.org/0000-0003-2006-1444

Funding

Agencia Nacional de Investigación y Desarrollo 11220870Agencia Nacional de Investigación y Desarrollo ACT210083Minera Escondida ltda MEL2203
6 · The paper itself

Abstract

backgroundOutstanding exercise performance has been associated with an exacerbated vagal outflow. Nevertheless, during high-altitude hypobaric-hypoxia (HH), there is a baroreflex-dependent parasympathetic withdrawal and exercise performance deterioration. Notably, vagal control is pivotal in exercise performance, and exogenous oxytocin (OXY) administration has been shown to enhance parasympathetic drive; however, no evidence shows their role in exercise performance during HH. Then, this study aimed to examine the effect of prolonged exogenous oxytocin (OXY) administration on exercise performance during hypobaric hypoxia (HH) in rats.

resultsA vehicle group (n = 6) and an OXY group (n = 6) performed incremental exercise and baroreflex tests during both normobaric normoxia (NN) and HH (PO

conclusionThe findings suggest prolonged OXY administration prevents impaired exercise performance and vagal control during short-term HH.

Indexed as

BaroreflexHypoxiaOxytocinPhysical Conditioning, AnimalAnimalsHeart RateMaleRatsRats, Sprague-DawleyVagus NerveOxytocinAutonomic controlBaroreflexHigh-altitudeParasympathetic

Identifiers

PMID39578887
PMCPMC11585223

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.