ArticleBMC oral health2024
Salivary microbiome variations in type 2 diabetes mellitus patients with different stages of periodontitis.
Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in the study of oral microbiota in association with T2DM: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Graph in Graph (GiG): A novel graph AI framework for integrating and interpreting medical and omics data.bioRxiv : the preprint server for biology · 2026Article
- Oral Manifestations of Prediabetes: A Narrative Review of an Early Diagnostic Window for Dental Practice.Cureus · 2026Review
- Salivary microbiota composition and caries status in children with hearing impairment: a cross-sectional comparative study.Clinical oral investigations · 2026Article
- Comparative Analysis of Oral Microbiome in Indian Type 2 Diabetes Mellitus (T2DM) and Periodontitis Cohorts.Diseases (Basel, Switzerland) · 2026Article
- Healthy lifestyle and periodontitis: a multi-omics cross-sectional study in a Chinese cohort.Journal of oral microbiology · 2026Article
- Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Oral-Gut Microbiota Crosstalk and Epigenetic Targets in Metabolic and Neuropsychiatric Diseases.Nutrients · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundTo investigate the difference of salivary microbiome composition in type 2 diabetes mellitus with different stages of periodontitis.
methods105 patients diagnosed with T2DM were divided into four groups according to the Stage of periodontitis.The 16 S rDNA hypervariable regions V3-V4 were amplified by polymerase chain reaction (PCR) after saliva DNA was extracted. The library was constructed and Illumina sequencing was performed. The sequencing results were compared with the silva 138 database, and the salivary microbiome of the four groups of patients was studied by species composition analysis, species difference analysis, principal coordinate analysis, and correlation analysis.
resultsThere were significant differences in alpha diversity of salivary microbiome among the four groups, but no difference in Beta diversity. At the phylum level, there was one differential bacteria-Firmicutes, while at the genus level, there were 16 differential bacteria. Spearman's correlation analysis identified significant correlations between periodontal health indices (PLI, SBI, AL and PD) and the abundances of over 13 genera, including Streptococcus, Gemella and Capnocytophaga, etc. Additionally, the duration of diabetes exhibited a positive correlation with AL and PD.
conclusionsThere are differences in salivary microbial composition in patients with type 2 diabetes mellitus with different stages of periodontitis. There is a correlation between some saliva microbiota and periodontal inflammation.
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