ArticleCommunications biology2024
Claustrum modulation drives altered prefrontal cortex dynamics and connectivity.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- New functional insights from the monkey claustrum.National science review · 2026Review
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.bioRxiv : the preprint server for biology · 2026Article
- Distinct orbitofrontal circuits with dorsal and ventral CA1 differentially regulate spatial memory and emotional behaviors.Frontiers in behavioral neuroscience · 2026Article
- The claustrum enhances neural variability by modulating the responsiveness of the prefrontal cortex.Nature communications · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study delves into the claustrum's role in modulating spontaneous and sensory-evoked network activity across cortical regions. Using mesoscale calcium imaging and Gi and Gq DREADDs in anesthetized mice, we show that decreasing claustral activity enhances prefrontal cortical activity, while activation reduces prefrontal cortical activity. This claustrum modulation also caused changes to the brain's large-scale functional networks, emphasizing the claustrum's ability to influence long-range functional connectivity in the cortex. Claustrum inhibition increased the local coupling between frontal cortex areas, but reduced the correlation between anterior medial regions and lateral/posterior regions, while also enhancing sensory-evoked responses in the visual cortex. These findings indicate the claustrum can participate in orchestrating neural communication across cortical regions through modulation of prefrontal cortical activity. These insights deepen our understanding of the claustrum's impact on prefrontal connectivity, large-scale network dynamics, and sensory processing, positioning the claustrum as a key node modulating large-scale cortical dynamics.
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Registered trials
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