Evidence map›Paper›PMID 39578594›Full record

ArticleLab animal2024

A revision to marble burying: video analysis during the marble burying task is imperative to understanding rodent behavior.

Lauren A Burgett, Theres B Alexander, Haley A Moya, Marcy A Kingsbury

Abstract read
PubMed Publisher
In one paragraph

Article in Lab animal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lauren A BurgettDepartment of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Lurie Center for Autism, Charlestown, MA, USA. l.burgett2022@gmail.com.ORCID 0000-0002-2170-7457
Theres B AlexanderDepartment of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Lurie Center for Autism, Charlestown, MA, USA.
Haley A MoyaDepartment of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Lurie Center for Autism, Charlestown, MA, USA.ORCID 0000-0002-5319-924X
Marcy A KingsburyDepartment of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Lurie Center for Autism, Charlestown, MA, USA. makingsbury@mgh.harvard.edu.

Funding

United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) AR220042
6 · The paper itself

Abstract

The translational value of the marble burying task (MBT) is debatable. Here we performed video analysis of behaviors during the MBT to accurately capture the details of all behaviors displayed during this task. Our results show that a count of marbles buried at the end of the task may not be a good translational correlate of the 'intentional marble burying' that the task is assumed to measure. Rather, the number of marbles buried may be measuring accidental marble burying due to 'rapid digging'. Video analysis during MBT provides a novel approach to characterize the many behaviors displayed during this task and may explain inconsistencies reported in the literature. However, the number of marbles buried at the end of the MBT may still have value as a screening test for anxiogenic or anxiolytic interventions. Any interventions that show significant alterations in the number of marbles buried can be pursued further through more robust and comprehensive behavior scoring methods.

Indexed as

Behavior, AnimalVideo RecordingAnimalsAnxietyMaleMice

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.