ArticleNature microbiology2024
Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes.
Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology, clinical and pathological features and outcomes of listeriosis in ruminants: a systematic review and meta-analysis.The veterinary quarterly · 2025Pooled it
- A single transcriptional regulator is crucial for the adaptation of Staphylococcus aureus to diverse niches.Proceedings. Biological sciences · 2026Article
- Host adaptation drives genome evolution and virulence diversification in a bacterial zoonotic pathogen.bioRxiv : the preprint server for biology · 2026Article
- A versatile multi-components mixed model for bacterial-Genome Wide association studies.Nature communications · 2026Article
- Large-scale phenotyping and comparative genomics reveal genetic features of Listeria persistence in epithelial cells.PLoS pathogens · 2026Article
- Translation control by altered start codon usage as a means of modulating the general stress response and virulence in Listeria monocytogenes.PLoS genetics · 2026Article
- Molecular Characterization ofInternational journal of women's health · 2026Article
- Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.Communications biology · 2025Article
- Listeriosis.Nature reviews. Disease primers · 2025Review
- Predominance of L. monocytogenes Lineage I Clones in Wastewater, Ruminants, and Natural Environments.Environmental microbiology · 2025Article
- Article
- Stress-dependent activation of themBio · 2025Article
Corrections and comments
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Authors and funding
26 authors.
Funding
Abstract
Microbial pathogenesis is mediated by the expression of virulence genes. However, as microbes with identical virulence gene content can differ in their pathogenic potential, other virulence determinants must be involved. Here, by combining comparative genomics and transcriptomics of a large collection of isolates of the model pathogen Listeria monocytogenes, time-lapse microscopy, in vitro evolution and in vivo experiments, we show that the individual stress responsiveness of L. monocytogenes isolates determines their respective levels of virulence in vivo and reflects their degree of host adaptation. The transcriptional signature that accounts for the heterogeneity in the virulence of L. monocytogenes species is mediated by the stress response regulator SigB and driven by differential stress responsiveness. The tuning of SigB pathway responsiveness is polygenic and influenced by multiple, individually rare gene variations. This study reveals an overarching determinant of microbial virulence, challenging the paradigm of accessory virulence gene content as the major determinant of intraspecies virulence heterogeneity.
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39578578What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.