ArticleNature neuroscience2024
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- Synchronization of behavioral and cardiac dynamics in larval zebrafish.Cell reports · 2026Article
- Robust maintenance of both stimulus location and amplitude in a working memory model based on dendritic bistability.bioRxiv : the preprint server for biology · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Prediction of neural activity in connectome-constrained recurrent networks.Nature neuroscience · 2025Article
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
- Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2025Article
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain.bioRxiv : the preprint server for biology · 2025Article
- Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration.Current biology : CB · 2025Article
- Multiscale information processing in the immune system.Frontiers in immunology · 2025Review
- Modular architecture confers robustness to damage and facilitates recovery in spiking neural networks modelingFrontiers in neuroscience · 2025Article
- Next-Generation Neurotechnologies Inspired by Motor Primitive Model for Restoring Human Natural Movement.Research (Washington, D.C.) · 2025Review
- The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus.bioRxiv : the preprint server for biology · 2024Article
- Wiring of a low-dimensional integrator network.Nature neuroscience · 2024Article
- Studying zebrafish nervous system structure and function in health and disease with electron microscopy.Development, growth & differentiation · 2023Review
- Cyclic structure with cellular precision in a vertebrate sensorimotor neural circuit.Current biology : CB · 2023Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
A long-standing goal in neuroscience is to understand how a circuit's form influences its function. Here, we reconstruct and analyze a synaptic wiring diagram of the larval zebrafish brainstem to predict key functional properties and validate them through comparison with physiological data. We identify modules of strongly connected neurons that turn out to be specialized for different behavioral functions, the control of eye and body movements. The eye movement module is further organized into two three-block cycles that support the positive feedback long hypothesized to underlie low-dimensional attractor dynamics in oculomotor control. We construct a neural network model based directly on the reconstructed wiring diagram that makes predictions for the cellular-resolution coding of eye position and neural dynamics. These predictions are verified statistically with calcium imaging-based neural activity recordings. This work demonstrates how connectome-based brain modeling can reveal previously unknown anatomical structure in a neural circuit and provide insights linking network form to function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.