Evidence map›Paper›PMID 39578482›Full record

ArticleNature communications2024

Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes.

Qi Hu, Yang Liu, Qiuyu Yue, Shuo Zhou, Xianghong Jin, Fan Lin, Xiao-Jun Huang, Junling Zhuang, Jin Lu, Xiaofei Gao and 1 more

Abstract readCase Reports
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qi Hu *Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, 100871, China.ORCID 0000-0001-6362-1195
Yang Liu *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100871, China.
Qiuyu YueMinistry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, 100871, China.
Shuo ZhouMinistry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, 100871, China.
Xianghong JinDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Fan LinPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100871, China.ORCID 0000-0002-0987-5917
Xiao-Jun HuangPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.ORCID 0000-0002-2145-6643
Junling ZhuangDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. zhuangjunling@pumch.cn.ORCID 0000-0002-1228-0551
Jin LuPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100871, China. jin1lu@sina.com.
Xiaofei GaoKey Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, 310030, Zhejiang, China. gaoxiaofei@westlake.edu.cn.ORCID 0000-0003-2799-7421
Hsiang-Ying LeeMinistry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, 100871, China. slee@pku.edu.cn.ORCID 0000-0002-1503-5818

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFA1103300National Natural Science Foundation of China (National Science Foundation of China) 82370124
6 · The paper itself

Abstract

The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common PRCA triggers. In vitro analyses reveal lenalidomide as a pivotal disruptor of erythropoiesis. Single-cell transcriptome analysis unveils hyperactive CD8

Indexed as

CD8-Positive T-LymphocytesErythrocytesErythropoiesisHistocompatibility Antigens Class ILenalidomideMultiple MyelomaRed-Cell Aplasia, PureAntineoplastic Combined Chemotherapy ProtocolsBone MarrowBortezomibDexamethasoneHumansMaleSingle-Cell AnalysisBortezomibDexamethasoneHistocompatibility Antigens Class ILenalidomide

Identifiers

PMID39578482
PMCPMC11584757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.