Evidence map›Paper›PMID 39578466›Full record

ArticleNature communications2024

Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen.

Gavuthami Murugesan, Rachel L Paterson, Rakesh Kulkarni, Veronica Ilkow, Richard J Suckling, Mary M Connolly, Vijaykumar Karuppiah, Robert Pengelly, Archana Jadhav, Jose Donoso and 22 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Gavuthami Murugesan *Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Rachel L Paterson *Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0001-6268-5947
Rakesh KulkarniImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-1603-4139
Veronica IlkowImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0003-3968-465X
Richard J SucklingImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-6962-6533
Mary M ConnollyImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Vijaykumar KaruppiahImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-9645-7958
Robert PengellyImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-4980-3707
Archana JadhavImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0001-9727-0493
Jose DonosoImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0001-8000-1262
Tiaan HeunisImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0003-1987-9484
Wilawan BunjobpolImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Gwilym PhilipsImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Kafayat OloladeImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Daniel KayImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Anshuk SarkarImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Claire BarberImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0001-9748-6665
Ritu RajImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Carole PerotImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Tressan GrantImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0009-0000-1177-9388
Agatha TreveilImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-5600-8189
Andrew WalkerImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0003-4715-4325
Marcin DembekImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0003-2831-3335
Dawn Gibbs-HoweImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Miriam HockImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0009-0007-4353-3738
Ricardo J CarreiraImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-7705-1354
Kate E AtkinImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0009-0000-4214-9450
Lucy DorrellImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.
Andrew KnoxImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-1073-2091
Sarah LeonardImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0003-3752-7300
Mariolina SalioImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK.ORCID 0000-0002-4821-3801
Luis F GodinhoImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK. luis.godinho@immunocore.com.ORCID 0000-0002-2135-5148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The non-polymorphic HLA-E molecule offers opportunities for new universal immunotherapeutic approaches to chronic infectious diseases. Chronic Hepatitis B virus (HBV) infection is driven in part by T cell dysfunction due to elevated levels of the HBV envelope (Env) protein hepatitis B surface antigen (HBsAg). Here we report the characterization of three genotypic variants of an HLA-E-binding HBsAg peptide, Env

Indexed as

CD8-Positive T-LymphocytesHepatitis B Surface AntigensHepatitis B virusHistocompatibility Antigens Class IHLA-E AntigensAmino Acid SequenceHepatitis B, ChronicHumansReceptors, Antigen, T-CellT-LymphocytesHepatitis B Surface AntigensHistocompatibility Antigens Class IHLA-E AntigensReceptors, Antigen, T-Cell

Identifiers

PMID39578466
PMCPMC11584656

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.