Evidence map›Paper›PMID 39578425›Full record

ArticleThe pharmacogenomics journal2024

Plasma concentrations of venetoclax and Pharmacogenetics correlated with drug efficacy in treatment naive leukemia patients: a retrospective study.

Yue Li, Qing Wan, Jiaqi Wan, Xiong Xiao, Jinfang Hu, Xintong Yang, Fancong Kong, Jieyu Wang, Baoquan Song, Zhentao Li and 3 more

Abstract read
In one paragraph

Article in The pharmacogenomics journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. OncoTargets and therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yue Li *Department of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Qing Wan *Department of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiaqi WanDepartment of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xiong XiaoDepartment of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jinfang HuDepartment of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xintong YangDepartment of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Fancong KongJiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Jieyu WangJiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Baoquan SongJiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhentao LiDepartment of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Fei LiJiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Simei RenNational Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. rensimei4162@bjhmoh.cn.
Hongwei PengDepartment of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. wavypeng1985@126.com.

Funding

Jiangxi Provincial Department of Science and Technology (Department of Science and Technology, Jiangxi Province) 20204BCJ23024National Natural Science Foundation of China (National Science Foundation of China) 81860035Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) J230022
6 · The paper itself

Abstract

Venetoclax (VEN) was the only Bcl-2 inhibitor approved yet and showed large differences in clinical efficacy. The aim of the study was to explore the relationships between the plasma concentration and efficacy of VEN, and identify potential influencing factors. A retrospective cohort study was conducted and a total of 76 trough (C

Indexed as

Antineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicSulfonamidesAdultAgedCytochrome P-450 CYP3AFemaleGenotypeHumansLeukemiaMaleMiddle AgedPharmacogeneticsRetrospective StudiesTreatment OutcomeYoung AdultAntineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicCYP3A5 protein, humanCytochrome P-450 CYP3ASulfonamidesvenetoclax

Identifiers

PMID39578425
PMCPMC11584383

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.