ArticleNature communications2024
Microstructural asymmetry in the human cortex.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Causal Mapping of Bodily Awareness and Mesoscale Circuit Organization in the Human Cingulate and Precuneus.Research square · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- Brain age gradients as intermediate phenotypes linking plasma p-tau217 to cognition in community-dwelling older adults.NPJ dementia · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- cuBNM: GPU-Accelerated Brain Network Modeling.bioRxiv : the preprint server for biology · 2025Article
- Brain region localization: a rapid Parkinson's disease detection method based on EEG signals.Medical & biological engineering & computing · 2025Article
- Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders.Brain : a journal of neurology · 2025Review
- Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
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13 authors.
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Abstract
The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across cortical layers. A similar anterior-posterior pattern is observed using in vivo Human Connectome Project (N = 1101) T1w/T2w microstructural data, with average cortical asymmetry showing the strongest similarity with post-mortem-based asymmetry of layer III. Moreover, microstructural asymmetry is found to be heritable, varies as a function of age and sex, and corresponds to intrinsic functional asymmetry. We also observe a differential association of language and markers of mental health with microstructural asymmetry patterns at the individual level, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes, possibly anchored in development. Last, we could show concordant evidence with alternative in vivo microstructural measures: magnetization transfer (N = 286) and quantitative T1 (N = 50). Together, our study highlights microstructural asymmetry in the human cortex and its functional and behavioral relevance.
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