Evidence map›Paper›PMID 39578364›Full record

ArticlePhysiological reports2024

Mitigating hemoglobin-induced nephropathy: ApoHb-hp protection of podocytes.

Daniela Lucas, Carlos Munoz, Quintin O'Boyle, Ivan S Pires, Andre F Palmer, Pedro Cabrales

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Sex-specific glomerular filtration rate changes in response to acute hemoglobin exposure.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniela LucasDepartment of Bioengineering, University of California San Diego, San Diego, California, USA.ORCID 0009-0005-0101-4628
Carlos MunozDepartment of Bioengineering, University of California San Diego, San Diego, California, USA.ORCID 0000-0003-4832-3661
Quintin O'BoyleWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-1499-9620
Ivan S PiresWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-4035-0027
Andre F PalmerWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-3378-3772
Pedro CabralesDepartment of Bioengineering, University of California San Diego, San Diego, California, USA.ORCID 0000-0002-8794-2839

Funding

Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
PEGylated megahemoglobin for use as a red blood cell substituteR01HL138116 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, KAUMAYA, PRAVIN T. P. · 2017 to 2020
$2.9M
Bioengineering a Dual Function Protein Construct to Detoxify Heme and HemoglobinR01HL159862 · NHLBI · OHIO STATE UNIVERSITY · PI BUEHLER, PAUL WERNER, CABRALES, PEDRO · 2021 to 2024
$2.6M
Bioengineering a novel therapeutic protein complex to minimize the effects of medical device induced hemolysisR01HL162120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BUEHLER, PAUL WERNER, CABRALES, PEDRO · 2022 to 2025
$2.6M
Aerosolized therapy for hemoglobin toxicity in the treatment of hemolytic diseasesR01HL158076 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, IRWIN, DAVID CHARLES · 2022 to 2025
$2.5M
Attenuating the Oxidative and Myocardial Side-Effects of Acellular HemoglobinR01HL126945 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, PALMER, ANDRE FRANCIS · 2016 to 2019
$1.7M
Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and DiseaseT32HL160507 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Andrew D. McCulloch · 2022 to 2026
$1.6M
NHLBI NIH HHS R01 HL126945NHLBI NIH HHS R01 HL138116NHLBI NIH HHS R01 HL159862NHLBI NIH HHS T32 HL105373NHLBI NIH HHS T32 HL160507NHLBI NIH HHS T32HL160507NIH HHS R01HL158076NIH HHS R01HL159862NIH HHS R01HL162120
6 · The paper itself

Abstract

This study investigates hemoglobin (Hb)-induced kidney injury and the protective role of the ApoHemoglobin-Haptoglobin (ApoHb-Hp) complex against heme and Hb damage. Hb facilitates oxygen (O

Indexed as

HaptoglobinsHemoglobinsPodocytesAnimalsCell LineMiceOxidative StressReactive Oxygen SpeciesHaptoglobinsHemoglobinsReactive Oxygen Speciesfiltration barrierHb scavengingheme scavenginghemoglobinhemoglobin toxicitypodocytesrenal damageROS

Identifiers

PMID39578364
PMCPMC11584305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.