ArticleGeroScience2025
DEAD-box RNA helicase DDX-23 mediates dietary restriction induced health span in Caenorhabditis elegans.
Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Streptococcus thermophilus remodels lipid metabolism to extend healthspan in Caenorhabditis elegans through NHR-49-Delta-9 desaturase axis.GeroScience · 2026Article
- Parental polystyrene nanoplastics exposure increases susceptibility to pathogen infection in offspring via H3K36me3-UPRCell communication and signaling : CCS · 2026Article
- Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis.Frontiers in immunology · 2026Article
- Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway.Frontiers in immunology · 2026Article
- Chelerythrine enhances anti-fungi immunity inFrontiers in immunology · 2026Article
- Jujuboside A extends healthspan and enhances resistance of oxidative stress inFrontiers in pharmacology · 2026Article
- Parental sodium benzoate diet induces fat accumulation in offspring via histone H3K9me3 and SKN-1/Nrf2.Current research in food science · 2026Article
- Ginkgolide a enhances the resistance to pathogen infection through mitochondrial unfolded protein response.Cellular and molecular life sciences : CMLS · 2025Article
- Parental S-adenosylmethionine diet defines offspring immune response via histone H3K4me3 complex and Endoplasmic Reticulum UPR.Cell communication and signaling : CCS · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Dietary restriction (DR) extends lifespan in diverse species, from yeast to mammals. However, its underlying mechanisms are not well understood. In this study, through using the tractable model Caenorhabditis elegans, we show a role for the DEAD-box RNA helicase, DDX-23 (homologous to mammal DDX23) as a regulator of healthspan in response to dietary restriction. Meanwhile, DDX-23 is also required for heat and oxidative stress response in C. elegans. Intriguingly, DDX-23 functions in the germline during adult to regulate dietary restriction-induced longevity. We then find that PHA-4/FOXA acts downstream of DDX-23 to mediate the transcriptional response of SOD-related genes and consequently the lifespan of the animals. Furthermore, we find that the DEAD-box RNA helicase, DDX-23 negatively regulates the healthy lifespan extension by up-regulating the expression of miR-231, and resulting in suppressing the activation of FOXO transcription factor DAF-16. Our work shows a newly discovered for DEAD-box RNA helicase DDX-23 in the regulation of dietary restriction-mediated longevity in C. elegans and reveals the downstream transcriptional regulation mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.