Evidence map›Paper›PMID 39578270›Full record

ArticlePediatric surgery international2024

Total colonic aganglionosis: management and long-term outcomes at a referral centre.

Shalini Gajanan Hegde, Rajkiran Srinivas Raju, Attibele Mahadevaiah Shubha, Kiran Mahadevappa, Prasanna Kumar, Mainak Deb, Suravi Mohanty, Kanishka Das

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Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shalini Gajanan HegdeDepartment of Paediatric Surgery, St. John's Medical College Hospital, Bengaluru, India.
Rajkiran Srinivas RajuDepartment of Paediatric Surgery, St. John's Medical College Hospital, Bengaluru, India.
Attibele Mahadevaiah ShubhaDepartment of Paediatric Surgery, St. John's Medical College Hospital, Bengaluru, India.
Kiran MahadevappaDepartment of Paediatric Surgery, St. John's Medical College Hospital, Bengaluru, India.
Prasanna KumarDepartment of Paediatric Surgery, St. John's Medical College Hospital, Bengaluru, India.
Mainak DebDepartment of Paediatric Surgery, Rainbow Hospitals, Hyderabad, India.
Suravi MohantyDepartment of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, India.
Kanishka DasDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India, 751019. kanishkadas@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe management of total colonic aganglionosis (TCA) in low-middle income countries (LMIC) is challenging. We aimed to analyze the profile, management, and outcome of patients with TCA at an Indian referral centre.

methodsA retrospective review of demography, presentation, investigations, and treatment of patients with TCA at a single centre over 22 years with a standardized protocol is detailed. Long-term outcome was assessed with qualitative evaluation and bowel function score.

resultsTwenty-two patients were reviewed. Although neonatal intestinal obstruction was common, 36% had chronic constipation. Delayed meconium history was evident in 54% and a classical microcolon in 28%. 71% of contrast enemas were incongruent with the final histological diagnosis. The median time on a levelled stoma was 13 months. 45.5% had 15 interim surgical interventions, including 8 relevelling (36%) before the definitive surgery at a median age of 19.5 months. At a mean follow-up age of 10.3 years, eleven had a bowel function score of ≥ 17 and five others had a favorable qualitative outcome.

conclusionThe diagnosis, histological levelling and management of TCA continues to be challenging in LMIC. The morbidity and long-term outcomes with the described protocol were comparable to studies from developed nations.

Indexed as

Hirschsprung DiseaseChildChild, PreschoolFemaleFollow-Up StudiesHumansIndiaInfantInfant, NewbornMaleRetrospective StudiesTreatment OutcomeBowel function scoreLow-middle income countriesManagementOutcomeTotal colonic aganglionosis

Identifiers

PMID39578270

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