Evidence map›Paper›PMID 39578261›Full record

ArticleClinical oral investigations2024

Association of RS1126478 (LTF) with molar-incisor and generalized periodontitis.

Camila S Stolf, Arthur G S Pereira, Bruna C Almeida, Hélvis E S Paz, Letícia S Arroteia, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Manuela M V Miguel, Laís F F Ferraz and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Camila S StolfDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Arthur G S PereiraDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Bruna C AlmeidaDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Hélvis E S PazDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Letícia S ArroteiaDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Hong HuangDepartment of Periodontology, University of Florida, Gainesville, FL, 32610, USA.
Ikramuddin AukhilDepartment of Periodontology, University of Florida, Gainesville, FL, 32610, USA.
Peter HarrisonDepartment of Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland.
Manuela M V MiguelDepartment of Diagnosis and Surgery, São José dos Campos School of Dentistry, São Paulo State University, São José dos Campos, São Paulo, Brazil.
Laís F F FerrazDepartment of Diagnosis and Surgery, São José dos Campos School of Dentistry, São Paulo State University, São José dos Campos, São Paulo, Brazil.
Mauro P SantamariaDepartment of Diagnosis and Surgery, São José dos Campos School of Dentistry, São Paulo State University, São José dos Campos, São Paulo, Brazil.
Luciana M ShaddoxDepartment of Oral Health Practice and Center of Oral Health Research, University of Kentucky College of Dentistry, Lexington, Kentucky, USA. lshaddox@uky.edu.ORCID 0000-0003-0948-1667
Renato C V CasarinDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. rcasarin@unicamp.br.ORCID 0000-0002-1037-591X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLTF SNP rs1126478 (T>C) could modulate Lactoferrin function and release and has been associated with periodontal disease in different locations before, but not in America. Thus, this study aimed to assess the association between this SNP and Grade C Periodontitis (Generalized (PerioC-G) and Molar Incisor Pattern (PerioC-MIP)) and seek a relationship between its presence and LTF gingival crevicular fluid (GCF) production. MATERIAL AND

methodsOral cells from 361 Brazilians and 375 North Americans patients (Diseased and Health Controls (PH) from both locations) were collected. DNA was extracted, and a prefabricated probe system determined rs116478 genotyping. Immunoenzymatic analysis detected LTF levels in GCF.

resultsHigher allelic altered-C frequency was associated with PerioC. For PerioC-G, CT and CC genotypes presented a frequency of 44.7% and 34.1%, respectively, while 37.3% and 26.4% were found to PH group (OD=2.1 (p=0.004) for CT and OD=2.3 (p=0.003) for CC). PerioC-G was associated with a lower concentration (742.2±717.9 pg/ml) of LTF than PerioC-MIP (5851±5859.2 pg/ml), p<0.0001. Multiple logistic regression showed that CC genotype impacted LTF levels by acting as a predictor (β =2.457, p=0.02, OD=1.17) despite the site or diagnosis.

conclusionThere is an association of rs1126478 with Grade C periodontitis, mainly the PerioC-G. Lower LTF levels in GCF might be associated with the generalized disease pattern. CLINICAL RELEVANCE: This study assessed and compared the genetic background in two distinct locations, paving the way for new studies regarding personalized risk and treatment for different ethnicities. As this SNP is in a region related to the antimicrobial function of LTF, it could impact PerioC-MIP and PerioC-G response against periodontopathogens. This discovery opens the way for in vitro studies analyzing the functionality of this SNP, and, in the future, it can be used to treat PerioC, individualizing the phenotypes.

Indexed as

GenotypeGingival Crevicular FluidLactoferrinPeriodontitisPolymorphism, Single NucleotideAdultBrazilFemaleHumansMaleMiddle AgedLactoferrinAggressive periodontitisGeneticsLactoferrinPolymorphism, single nucleotideProtein

Identifiers

PMID39578261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.